Casp4 - caspase 4, apoptosis-related cysteine peptidase Gene

Mus musculus

Also known as Caspl; ich-3; CASP-4; Casp11; CASP-11

Gene ID: 12363 | Gene type: protein coding

About Casp4

Chromosome 9: 5,308,828-5,336,783 forward strand.GRCm39:CM001002.3

This gene has 7 transcripts (splice variants), 252 orthologues, 11 paralogues and is associated with 21 phenotypes. Biased expression in large intestine adult (RPKM 7.7), bladder adult (RPKM 4.) and 14 other tissues.

Summary

This gene encodes a member of the cysteine proteases that plays important roles in Apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon Bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called Caspase 11. This gene is present in a cluster of three Caspase genes on chromosome 9. [provided by RefSeq, Apr 2015]

Casp4 Products(8)

mRNA	Protein	Name
NM_001379320.1	NP_001366249.1	caspase-4 isoform 4
NM_001379318.1	NP_001366247.1	caspase-4 isoform 2
NM_001379319.1	NP_001366248.1	caspase-4 isoform 3
NM_001379321.1	NP_001366250.1	caspase-4 isoform 5
NM_001379323.1	NP_001366252.1	caspase-4 isoform 7
NM_007609.3	NP_031635.2	caspase-4 isoform 1
NM_001379322.1	NP_001366251.1	caspase-4 isoform 6
NM_001379321.1	NP_001366250.1	caspase-4 isoform 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	30135078	MGI
enables cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	30392956	MGI
enables lipid binding	IDA IDA: Inferred from direct assay	25119034	MGI
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	25119034	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	30692621	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	30392956	MGI
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	25119034	MGI
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	23348507	MGI
involved in detection of lipopolysaccharide	IDA IDA: Inferred from direct assay	23887873	MGI
acts upstream of or within ectopic germ cell programmed cell death	IGI IGI: Inferred from genetic interaction	11536012	MGI
acts upstream of or within ectopic germ cell programmed cell death	IMP IMP: Inferred from mutant phenotype	11536012	MGI
acts upstream of interleukin-1 beta production	IGI IGI: Inferred from genetic interaction	22002608	MGI
acts upstream of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	22002608	MGI
involved in non-canonical inflammasome complex assembly	IDA IDA: Inferred from direct assay	23887873	MGI
involved in non-canonical inflammasome complex assembly	IMP IMP: Inferred from mutant phenotype	22895188	MGI
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	26173909	MGI
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	30392956	MGI
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	23348507	MGI
acts upstream of or within positive regulation of interleukin-1 beta production	IGI IGI: Inferred from genetic interaction	22002608	MGI
involved in positive regulation of interleukin-18-mediated signaling pathway	IDA IDA: Inferred from direct assay	30392956	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	22002608	MGI
involved in protein autoprocessing	IDA IDA: Inferred from direct assay	32109412	MGI
involved in protein autoprocessing	IMP IMP: Inferred from mutant phenotype	30392956	MGI
involved in protein maturation	IDA IDA: Inferred from direct assay	30135078	MGI
involved in pyroptotic cell death	IDA IDA: Inferred from direct assay	38632402	MGI
involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	30135078	MGI
acts upstream of or within pyroptotic inflammatory response	IMP IMP: Inferred from mutant phenotype	22002608	MGI
involved in pyroptotic inflammatory response	IMP IMP: Inferred from mutant phenotype	23348507	MGI
involved in regulation of inflammatory response	IDA IDA: Inferred from direct assay	32109412	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	16670335	MGI
is active in cytosol	IDA IDA: Inferred from direct assay	16670335	MGI
part of non-canonical inflammasome complex	IDA IDA: Inferred from direct assay	23887873	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp4 Protein Structure

CARD_CASP1-like

CASc

0
100
200
300
373 a.a.

Protein Preferred Names

Protein Names

caspase-4

caspase 11, apoptosis-related cysteine peptidase	caspase 11, apoptosis-related cysteine protease
caspase 4, apoptosis-related cysteine protease	caspase-11 short form splicing
protease ICH-3

Casp4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80588	Caspase 11 Antibody	WB, IP	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01955	CASP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01956	Casp4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01957	Casp4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Casp4	NCBI	NCBI:837

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