2. Gene
  3. Cckbr - cholecystokinin B receptor Gene

Cckbr - cholecystokinin B receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CCK2R; CCK-BR; CCK2-R; CCKR-2

Gene ID: 12426 | Gene type: protein coding

About Cckbr

Chromosome 7: 105,074,938-105,120,105 forward strand.GRCm39:CM001000.3

This gene has 2 transcripts (splice variants), 268 orthologues, 16 paralogues and is associated with 37 phenotypes. Biased expression in cortex adult (RPKM 23.1), frontal lobe adult (RPKM 18.4) and 3 other tissues.

Summary

This gene encodes a multipass transmembrane receptor protein expressed in the central nervous system and gastrointestinal tract. Cholecystokinin and Gastrin bind to the encoded protein to stimulate gastric acid secretion and mucosal growth in the gastrointestinal tract, and anxiety, pain sensation and memory in the brain. Mice lacking the encoded protein exhibit an increase in the basal gastric pH and Gastrin levels in the bloodstream as well as mild hypocalcemia, secondary hyperparathyroidism and increased bone resorption. [provided by RefSeq, Apr 2015]

Cckbr Products(2)

mRNA Protein Name
NM_007627.6 NP_031653.1 gastrin/cholecystokinin type B receptor isoform 1
NM_001412224.1 NP_001399153.1 gastrin/cholecystokinin type B receptor isoform 2

Cckbr Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (54 - 406)

7tm_GPCRs

7tm_GPCRs: cd14964 (56 - 80)

7tm_GPCRs

7tm_GPCRs: cd14964 (89 - 111)

7tm_GPCRs

7tm_GPCRs: cd14964 (127 - 149)

7tm_GPCRs

7tm_GPCRs: cd14964 (172 - 188)

7tm_GPCRs

7tm_GPCRs: cd14964 (215 - 238)

7tm_GPCRs

7tm_GPCRs: cd14964 (337 - 359)

7tm_GPCRs

7tm_GPCRs: cd14964 (374 - 399)

  • 0
  • 100
  • 200
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  • 400
  • 453 a.a.
Protein Preferred Names Protein Names

gastrin/cholecystokinin type B receptor

CCK-B receptor

CCK-B/gastrin receptor

CCK2/gastrin receptor

cholecystokinin-2 receptor

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0261 Pentagastrin Activator 99.97% Unkown
Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-19445 Gastrazole Antagonist / Phase 3
HY-106840 L-365260 Antagonist 99.93% Phase 2
HY-106347 Itriglumide Antagonist / Phase 2
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1097 Gastrin I, human 99.93% Unkown
HY-129810 PD 135158 Antagonist / Unkown
HY-123434 PD-149164 Agonist / Unkown
HY-155205 GV150013X Antagonist / Unkown
HY-111313 JNJ-26070109 Antagonist / Unkown
HY-119127 TP-680 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cckbr NCBI NCBI:887