Cckbr - cholecystokinin B receptor Gene

Mus musculus

Also known as CCK2R; CCK-BR; CCK2-R; CCKR-2

Gene ID: 12426 | Gene type: protein coding

About Cckbr

Chromosome 7: 105,074,938-105,120,105 forward strand.GRCm39:CM001000.3

This gene has 2 transcripts (splice variants), 268 orthologues, 16 paralogues and is associated with 37 phenotypes. Biased expression in cortex adult (RPKM 23.1), frontal lobe adult (RPKM 18.4) and 3 other tissues.

Summary

This gene encodes a multipass transmembrane receptor protein expressed in the central nervous system and gastrointestinal tract. Cholecystokinin and Gastrin bind to the encoded protein to stimulate gastric acid secretion and mucosal growth in the gastrointestinal tract, and anxiety, pain sensation and memory in the brain. Mice lacking the encoded protein exhibit an increase in the basal gastric pH and Gastrin levels in the bloodstream as well as mild hypocalcemia, secondary hyperparathyroidism and increased bone resorption. [provided by RefSeq, Apr 2015]

Cckbr Products(2)

mRNA	Protein	Name
NM_007627.6	NP_031653.1	gastrin/cholecystokinin type B receptor isoform 1
NM_001412224.1	NP_001399153.1	gastrin/cholecystokinin type B receptor isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8876222	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within digestive tract development	IMP IMP: Inferred from mutant phenotype	15476751	MGI
acts upstream of or within gastric acid secretion	IGI IGI: Inferred from genetic interaction	15476751	MGI
acts upstream of or within gastric acid secretion	IMP IMP: Inferred from mutant phenotype	15476751	MGI
acts upstream of or within gland development	IMP IMP: Inferred from mutant phenotype	15476751	MGI
acts upstream of or within pH reduction	IMP IMP: Inferred from mutant phenotype	19448635	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	8876222	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cckbr Protein Structure

7tm_GPCRs

0
100
200
300
400
453 a.a.

Protein Preferred Names

Protein Names

gastrin/cholecystokinin type B receptor

CCK-B receptor	CCK-B/gastrin receptor
CCK2/gastrin receptor	cholecystokinin-2 receptor

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0261	Pentagastrin	Activator	99.97%	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19445	Gastrazole	Antagonist	/	Phase 3
HY-106840	L-365260	Antagonist	99.93%	Phase 2
HY-17617	Nastorazepide	Antagonist	99.95%	Phase 2
HY-106347	Itriglumide	Antagonist	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1097	Gastrin I, human		99.93%	Unkown
HY-129357	CCK-B Receptor Antagonist 2	Inhibitor	98.84%	Unkown
HY-129810	PD 135158	Antagonist	/	Unkown
HY-123434	PD-149164	Agonist	/	Unkown
HY-155205	GV150013X	Antagonist	/	Unkown
HY-111313	JNJ-26070109	Antagonist	/	Unkown
HY-119127	TP-680	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cckbr	NCBI	NCBI:887

Name
Email *

	Sorry, but the email address you supplied was invalid.