WFIKKN2 - WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 Gene

Homo sapiens

Also known as GASP-1; WFDC20B; hGASP-1; WFIKKNRP

Gene ID: 124857 | Gene type: protein coding

About WFIKKN2

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,834,584-50,842,353 (from NCBI)

This gene has 2 transcripts (splice variants), 148 orthologues and 13 paralogues. Biased expression in ovary (RPKM 30.8) and testis (RPKM 1.8).

Summary

The WFIKKN1 protein contains a WAP domain, Follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, Follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]

WFIKKN2 Products(2)

mRNA	Protein	Name
NM_001330341.2	NP_001317270.1	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform 2
NM_175575.6	NP_783165.1	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18596030	GOA
enables receptor antagonist activity	IDA IDA: Inferred from direct assay	21054789	GOA
enables transforming growth factor beta binding	IDA IDA: Inferred from direct assay	21054789	GOA
enables transforming growth factor beta binding	IPI IPI: Inferred from physical interaction	12595574	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	21054789	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12595574	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WFIKKN2 Protein Structure

WAP

Kazal_2

I-set

Kunitz_BPTI

NTR

0
100
200
300
400
500
576 a.a.

Protein Preferred Names

Protein Names

WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

WAP four-disulfide core domain 20B

Recombinant WFIKKN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75173	GASP-1/WFIKKN2 Protein, Human (HEK293, His)	Q8TEU8 (L35-H576)	≥95%

Related Diseases

Diseases

Alias

Space Motion Sickness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15812	WFIKKN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WFIKKN2	MGD	MGI:2669209
Bos taurus	WFIKKN2	VGNC	VGNC:55888
Canis familiaris	WFIKKN2	VGNC	VGNC:104174
Felis catus	WFIKKN2	VGNC	VGNC:99574
Macaca mulatta	WFIKKN2	VGNC	VGNC:79900
Rattus norvegicus	WFIKKN2	RGD	RGD:1305361
Others	WFIKKN2	NCBI

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