SPACA3 - sperm acrosome associated 3 Gene

Homo sapiens

Also known as CT54; LYC3; LYZC; LYZL3; SLLP1; ALLP17

Gene ID: 124912 | Gene type: protein coding

About SPACA3

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:32,991,847-32,997,877 (from NCBI)

This gene has 5 transcripts (splice variants), 121 orthologues and 8 paralogues. Restricted expression toward testis (RPKM 20.0).

Summary

The protein encoded by this gene is a sperm surface protein that may be involved in adhesion to the egg prior to fertilization. While the encoded protein has significant similarity to lysozyme at the amino acid level, it has no detectable bacteriocidal activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

SPACA3 Products(3)

mRNA	Protein	Name
NM_001317225.2	NP_001304154.1	sperm acrosome membrane-associated protein 3 isoform 3
NM_001317226.2	NP_001304155.1	sperm acrosome membrane-associated protein 3 isoform 2
NM_173847.5	NP_776246.1	sperm acrosome membrane-associated protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables lysozyme activity	IDA IDA: Inferred from direct assay	12606493	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19945174	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fusion of sperm to egg plasma membrane involved in single fertilization	IMP IMP: Inferred from mutant phenotype	15982649	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in acrosomal matrix	IDA IDA: Inferred from direct assay	12606493	GOA
located in acrosomal membrane	IDA IDA: Inferred from direct assay	12606493	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPACA3 Protein Structure

Lys

0
100
200
215 a.a.

Protein Preferred Names

Protein Names

sperm acrosome membrane-associated protein 3

cancer/testis antigen 54

Related Diseases

Diseases

Alias

Immunoglobulin Heavy-And-Light Chain

Ah/Al Amyloidosis

Ig Heavy-And-Light-Chain Amyloidosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13616	SPACA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SPACA3	MGD	MGI:1922872
Bos taurus	SPACA3	VGNC	VGNC:55872
Rattus norvegicus	SPACA3	RGD	RGD:1306684
Macaca mulatta	SPACA3	VGNC	VGNC:77930
Canis familiaris	SPACA3	VGNC	VGNC:46693
Felis catus	SPACA3	VGNC	VGNC:65591

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