Scarb2 - scavenger receptor class B, member 2 Gene

Mus musculus

Also known as LGP85; Cd36l2; LIMP-2; MLGP85; LIMP II; 9330185J12Rik

Gene ID: 12492 | Gene type: protein coding

About Scarb2

Summary

This gene encodes a CD36-like type III Transmembrane Glycoprotein that localizes to the lysosomal membrane. Mice lacking the encoded protein exhibit an increased postnatal mortality caused by an obstruction of the ureteropelvic junction, deafness, peripheral demyelinating neuropathy and tubular proteinuria. [provided by RefSeq, Aug 2015]

Scarb2 Products(1)

mRNA	Protein	Name
NM_007644.4	NP_031670.1	lysosome membrane protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cargo receptor activity	IMP IMP: Inferred from mutant phenotype	18022370	MGI
enables cholesterol binding	IDA IDA: Inferred from direct assay	29199275	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	18022370	MGI
enables phosphatidylcholine binding	IDA IDA: Inferred from direct assay	29199275	MGI
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	29199275	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	27789271	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	29199275	MGI
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	27789271	MGI
enables scavenger receptor activity	IDA IDA: Inferred from direct assay	29199275	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in aminophospholipid transport	IDA IDA: Inferred from direct assay	29199275	MGI
acts upstream of or within endosome to plasma membrane protein transport	IMP IMP: Inferred from mutant phenotype	16901941	MGI
involved in protein targeting to lysosome	IMP IMP: Inferred from mutant phenotype	18022370	MGI
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	29199275	MGI
involved in regulation of carbohydrate catabolic process	IMP IMP: Inferred from mutant phenotype	18022370	MGI
involved in regulation of glucosylceramidase activity	IMP IMP: Inferred from mutant phenotype	25316793	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	16901941	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endocytic vesicle membrane	IDA IDA: Inferred from direct assay	29199275	MGI
located in lysosomal lumen	IDA IDA: Inferred from direct assay	18022370	MGI
located in lysosomal membrane	IDA IDA: Inferred from direct assay	18022370	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	29199275	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lysosome membrane protein 2

85 kDa lysosomal membrane sialoglycoprotein	CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2
lysosome membrane protein II

Recombinant Scarb2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72515	LIMPII/SR-B2 Protein, Mouse (406a.a, HEK293, His)	O35114 (R27-T432)	≥95%
HY-P72895	CD36 Protein, Mouse (HEK293, His)	Q08857 (G30-K439)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12489	SCARB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scarb2	NCBI	NCBI:950

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