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  3. Receptor Proteins
  4. LIMPII/SR-B2 Protein, Mouse (406a.a, HEK293, His)

LIMPII/SR-B2 Protein, Mouse (406a.a, HEK293, His)

Cat. No.: HY-P72515
Handling Instructions

LIMPII/SR-B2 Protein acts as a lysosomal receptor crucial for targeting glucosylceramidase (GBA1) to lysosomes. This interaction highlights its role in intracellular trafficking, ensuring the specific recognition and delivery of GBA1 to the lysosomal environment. The protein's direct interaction with GBA1 contributes to essential cellular processes related to lipid metabolism and degradation. LIMPII/SR-B2 Protein, Mouse (406a.a, HEK293, His) is the recombinant mouse-derived LIMPII/SR-B2 protein, expressed by HEK293, with C-6*His labeled tag. The total length of LIMPII/SR-B2 Protein, Mouse (406a.a, HEK293, His) is 406 a.a., with molecular weight of 65-90 kDa.

For research use only. We do not sell to patients.

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Description

LIMPII/SR-B2 Protein acts as a lysosomal receptor crucial for targeting glucosylceramidase (GBA1) to lysosomes. This interaction highlights its role in intracellular trafficking, ensuring the specific recognition and delivery of GBA1 to the lysosomal environment. The protein's direct interaction with GBA1 contributes to essential cellular processes related to lipid metabolism and degradation. LIMPII/SR-B2 Protein, Mouse (406a.a, HEK293, His) is the recombinant mouse-derived LIMPII/SR-B2 protein, expressed by HEK293, with C-6*His labeled tag. The total length of LIMPII/SR-B2 Protein, Mouse (406a.a, HEK293, His) is 406 a.a., with molecular weight of 65-90 kDa.
Background

LIMPII/SR-B2 Protein functions as a lysosomal receptor that plays a crucial role in the targeting of glucosylceramidase (GBA1) to the lysosomes. This interaction underscores its involvement in the intracellular trafficking and localization of GBA1 within the lysosomal compartment. The protein directly interacts with GBA1, facilitating the specific recognition and delivery of this enzyme to the lysosomal environment, thereby contributing to essential cellular processes associated with lipid metabolism and degradation.
Species

Mouse
Source

HEK293
Tag

C-6*His
Accession

O35114 (R27-T432)
Gene ID
Molecular Construction
N-term
LIMPII (R27-T432)
Accession # O35114
6*His
C-term
Synonyms
Lysosome membrane protein 2; LGP85; LIMP II; Scarb2
AA Sequence

RVFQKAVDQTIEKNMVLQNGTKVFNSWEKPPLPVYIQFYFFNVTNPEEILQGEIPLLEEVGPYTYRELRNKANIQFGENGTTISAVTNKAYVFERNQSVGDPNVDLIRTINIPLLTVVDLAQLTLLRELIEAMLKAYQQKLFVIHTVHELLWGYKDEILSLVHIFKPDVSPNFGLFYERNGTNDGEYVFLTGEDNYLNFSKIVEWNGKTSLDWWTTDTCNMINGTDGDSFHPLISKDEVLYLFPSDLCRSVHITFSSFENVEGLPAFRYKVPAEILANTSENAGFCIPEGNCMDSGVLNISICKNGAPIIMSFPHFYQADEKFVSAIKGMHPNKEEHESFVDINPLTGIILRGAKRFQINTYVRKLDDFVETGDIRTMVFPVMYLNESVLIDKETANQLKSVINTT

Molecular Weight

65-90 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

LIMPII/SR-B2 Protein, Mouse (406a.a, HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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