Cdh2 - cadherin 2 Gene

Mus musculus

Also known as CDHN; Ncad; N-CAD

Gene ID: 12558 | Gene type: protein coding

About Cdh2

Summary

This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Mice lacking the encoded protein exhibit severe developmental defects resulting in embryonic death. [provided by RefSeq, Oct 2015]

Cdh2 Products(1)

mRNA	Protein	Name
NM_007664.5	NP_031690.3	cadherin-2 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	27783602	MGI
enables calcium ion binding	IDA IDA: Inferred from direct assay	9655503	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	24952463	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	20190754	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11106648	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	23392350	MGI
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	16973135	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	15809310	MGI
acts upstream of or within brain morphogenesis	IGI IGI: Inferred from genetic interaction	25100583	MGI
acts upstream of or within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IDA IDA: Inferred from direct assay	14561752	MGI
acts upstream of or within cell adhesion	IDA IDA: Inferred from direct assay	12738802	MGI
acts upstream of or within cell migration	IDA IDA: Inferred from direct assay	14561752	MGI
involved in cell-cell adhesion	IDA IDA: Inferred from direct assay	9655503	MGI
involved in cell-cell adhesion mediated by cadherin	IDA IDA: Inferred from direct assay	24952463	MGI
involved in cell-cell junction assembly	IMP IMP: Inferred from mutant phenotype	26750727	MGI
acts upstream of or within cerebral cortex development	IGI IGI: Inferred from genetic interaction	25100583	MGI
involved in glial cell differentiation	IDA IDA: Inferred from direct assay	24952463	MGI
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA IDA: Inferred from direct assay	8270638	MGI
acts upstream of or within homeostasis of number of cells	IGI IGI: Inferred from genetic interaction	25100583	MGI
acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules	IDA IDA: Inferred from direct assay	8270638	MGI
acts upstream of or within mesenchymal cell migration	IMP IMP: Inferred from mutant phenotype	17507657	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	19075000	MGI
involved in neural crest cell development	IMP IMP: Inferred from mutant phenotype	26750727	MGI
acts upstream of or within neuroepithelial cell differentiation	IGI IGI: Inferred from genetic interaction	25100583	MGI
involved in neuroligin clustering involved in postsynaptic membrane assembly	IMP IMP: Inferred from mutant phenotype	20534458	MGI
involved in neuronal stem cell population maintenance	IDA IDA: Inferred from direct assay	24952463	MGI
acts upstream of or within positive regulation of MAPK cascade	IGI IGI: Inferred from genetic interaction	20160094	MGI
involved in positive regulation of synaptic vesicle clustering	IMP IMP: Inferred from mutant phenotype	20534458	MGI
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	24046456	MGI
acts upstream of or within radial glial cell differentiation	IGI IGI: Inferred from genetic interaction	25100583	MGI
acts upstream of or within regulation of oligodendrocyte progenitor proliferation	IGI IGI: Inferred from genetic interaction	25100583	MGI
involved in regulation of postsynaptic density protein 95 clustering	IMP IMP: Inferred from mutant phenotype	20534458	MGI
acts upstream of or within striated muscle cell differentiation	IGI IGI: Inferred from genetic interaction	20160094	MGI
involved in synaptic vesicle clustering	IMP IMP: Inferred from mutant phenotype	34702855	MGI
acts upstream of or within telencephalon development	IGI IGI: Inferred from genetic interaction	25100583	MGI
involved in type B pancreatic cell development	IMP IMP: Inferred from mutant phenotype	26750727	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	12052883	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	21947081	MGI
located in apicolateral plasma membrane	IDA IDA: Inferred from direct assay	29211732	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	25512490	MGI
located in cell surface	IDA IDA: Inferred from direct assay	25232112	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	21296051	MGI
located in desmosome	IDA IDA: Inferred from direct assay	15479741	MGI
located in fascia adherens	IDA IDA: Inferred from direct assay	11732910	MGI
located in intercalated disc	IDA IDA: Inferred from direct assay	17884088	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	14657280	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	9655503	MGI
located in plasma membrane raft	IDA IDA: Inferred from direct assay	24046456	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	23392350	MGI
located in synapse	IDA IDA: Inferred from direct assay	14622577	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cadherin-2

N-cadherin

neural cadherin

Recombinant Cdh2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73750	N-Cadherin Protein, Mouse (HEK293)	P15116 (S26-A724)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02330	CDH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdh2	NCBI	NCBI:1000

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