CNGA2 - cyclic nucleotide gated channel subunit alpha 2 Gene

Homo sapiens

Also known as CNCA; CNG2; CNCA1; OCNC1; OCNCa; OCNCALPHA

Gene ID: 1260 | Gene type: protein coding

About CNGA2

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:151,734,746-151,745,564 (from NCBI)

This gene has 1 transcript (splice variant), 268 orthologues, 17 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]

CNGA2 Products(1)

mRNA	Protein	Name
NM_005140.3	NP_005131.1	cyclic nucleotide-gated olfactory channel

CNGA2 Protein Structure

Ion_trans

cNMP_binding

0
200
400
600
664 a.a.

Protein Preferred Names

Protein Names

cyclic nucleotide-gated olfactory channel

CNG channel alpha-2

Related Diseases

Diseases

Alias

Anosmia, Isolated Congenital

ANIC	Isolated Congenital Anosmia
Anosmia, Congenital	Congenital Anosmia

Retinitis Pigmentosa 45

RP45	Retinitis Pigmentosa, Type 45

Achromatopsia 2

ACHM2	Rod Monochromatism 2
Rod Monochromacy 2	Rmch2
Colorblindness, Total	Complete Achromatopsia
Total Colorblindness	Achromatopsia-2
Achromatopsia, Type 2	Color Blindness
Achromatopsia

Seckel Syndrome 7

SCKL7	Microcephalic Primordial Dwarfism, Dauber Type
Seckel Syndrome, Type 7

Orofaciodigital Syndrome Ix

OFD9	Orofaciodigital Syndrome With Retinal Abnormalities
Oral-Facial-Digital Syndrome With Retinal Abnormalities	Orofaciodigital Syndrome 9
Oral-Facial-Digital Syndrome Type 9	Ofds Ix
Oral-Facial-Digital Syndrome, Type Ix	Ofd Syndrome 9
Ofds 9	Oral Facial Digital Syndrome 9
Oral Facial Digital Syndrome Type 9	Orofaciodigital Syndrome Type 9
Orofaciodigital Syndrome, Type Ix

Retinitis Pigmentosa 83

RP83	Retinitis Pigmentosa, Type 83

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02880	CNGA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CNGA2	RGD	RGD:2367
Canis familiaris	CNGA2	VGNC	VGNC:39396
Bos taurus	CNGA2	VGNC	VGNC:27498
Felis catus	CNGA2	VGNC	VGNC:61012
Mus musculus	CNGA2	MGD	MGI:108040

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