OSCAR - osteoclast associated Ig-like receptor Gene

Homo sapiens

Also known as PIGR3; PIgR-3

Gene ID: 126014 | Gene type: protein coding

About OSCAR

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,094,668-54,100,803 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 224 orthologues and 25 paralogues. Biased expression in lung (RPKM 7.4), bone marrow (RPKM 7.3) and 12 other tissues.

Summary

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

OSCAR Products(6)

mRNA	Protein	Name
NM_001282349.3	NP_001269278.1	osteoclast-associated immunoglobulin-like receptor isoform 6 precursor
NM_001282350.3	NP_001269279.1	osteoclast-associated immunoglobulin-like receptor isoform 7 precursor
NM_130771.6	NP_570127.3	osteoclast-associated immunoglobulin-like receptor isoform 3 precursor
NM_133168.6	NP_573398.2	osteoclast-associated immunoglobulin-like receptor isoform 5 precursor
NM_133169.6	NP_573399.2	osteoclast-associated immunoglobulin-like receptor isoform 4 precursor
NM_206818.4	NP_996554.2	osteoclast-associated immunoglobulin-like receptor isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables collagen receptor activity	IDA IDA: Inferred from direct assay	21841309	GOA
enables collagen receptor activity	IMP IMP: Inferred from mutant phenotype	21841309	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	21841309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSCAR Protein Structure

Ig_2

0
100
200
286 a.a.

Protein Preferred Names

Protein Names

osteoclast-associated immunoglobulin-like receptor

osteoclast associated receptor OSCAR-S1

Recombinant OSCAR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78011	OSCAR Protein, Human (HEK293, Fc)	Q8IYS5-2 (D19-N229)	≥95%

Related Diseases

Diseases

Alias

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09847	OSCAR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	OSCAR	NCBI	NCBI:232790

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