HMGB4 - high mobility group box 4 Gene

Homo sapiens

Also known as dJ1007G16.5

Gene ID: 127540 | Gene type: protein coding

About HMGB4

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:33,860,475-33,864,791 (from NCBI)

This gene has 5 transcripts (splice variants), 255 orthologues and 20 paralogues. Restricted expression toward testis (RPKM 70.9).

Summary

Predicted to enable DNA binding activity, bending. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

HMGB4 Products(3)

mRNA	Protein	Name
NM_001352984.2	NP_001339913.1	high mobility group protein B4 isoform 2
NM_001379301.1	NP_001366230.1	high mobility group protein B4 isoform 1
NM_145205.6	NP_660206.2	high mobility group protein B4 isoform 1

HMGB4 Protein Structure

HMG_box_2

HMG_box

0
100
186 a.a.

Protein Preferred Names

Protein Names

high mobility group protein B4

HMG2 like

HMGB4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HMGB4	Q8WW32	KRTAP12-4	Homo sapiens	P60329	Y2H Prey Pooling	25416956
Intra	HMGB4	Q8WW32	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	25416956
Intra	HMGB4	Q8WW32	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	HMGB4	Q8WW32	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06235	HMGB4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HMGB4	RGD	RGD:1596426
Bos taurus	HMGB4	VGNC	VGNC:29876
Canis familiaris	HMGB4	VGNC	VGNC:41711
Felis catus	HMGB4	VGNC	VGNC:82378
Macaca mulatta	HMGB4	VGNC	VGNC:73437
Mus musculus	HMGB4	MGD	MGI:1916567

Name
Email *

	Sorry, but the email address you supplied was invalid.