2. Gene
  3. DNAH14 - dynein axonemal heavy chain 14 Gene

DNAH14 - dynein axonemal heavy chain 14 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HL18; HL-18; C1orf67; Dnahc14

Gene ID: 127602 | Gene type: protein coding

About DNAH14

Cytogenetic location: 1q42.12 Genomic coordinates (GRCh38): 1:224,929,654-225,399,286 (from NCBI)

This gene has 20 transcripts (splice variants), 108 orthologues, 15 paralogues and is associated with 1 phenotype. Biased expression in testis (RPKM 2.0), thyroid (RPKM 0.3) and 6 other tissues.

Summary

Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).[supplied by OMIM, Mar 2008]

DNAH14 Products(6)

mRNA Protein Name
NM_001145154.3 NP_001138626.1 dynein axonemal heavy chain 14 isoform 2
NM_001349911.2 NP_001336840.1 dynein axonemal heavy chain 14 isoform 4
NM_001349912.2 NP_001336841.1 dynein axonemal heavy chain 14 isoform 5
NM_001367479.1 NP_001354408.1 dynein axonemal heavy chain 14 isoform 7
NM_001367481.1 NP_001354410.1 dynein axonemal heavy chain 14 isoform 6
NM_144989.3 NP_659426.2 dynein axonemal heavy chain 14 isoform 3

DNAH14 Protein Structure

AAA_6

AAA_6: Hydrolytic ATP binding site of dynein motor region D1 (1126 - 1180)

AAA_6

AAA_6: Hydrolytic ATP binding site of dynein motor region D1 (1220 - 1327)

AAA_8

AAA_8: P-loop containing dynein motor region D4 (2011 - 2243)

MT

MT: Microtubule-binding stalk of dynein motor (2258 - 2488)

AAA_9

AAA_9: ATP-binding dynein motor region D5 (2496 - 2575)

AAA_9

AAA_9: ATP-binding dynein motor region D5 (2582 - 2687)

Dynein_heavy

Dynein_heavy: Dynein heavy chain and region D6 of dynein motor (3017 - 3073)

Dynein_heavy

Dynein_heavy: Dynein heavy chain and region D6 of dynein motor (3072 - 3279)

Dynein_heavy

Dynein_heavy: Dynein heavy chain and region D6 of dynein motor (3318 - 3503)

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  • 3507 a.a.
Protein Preferred Names Protein Names

dynein axonemal heavy chain 14

axonemal beta dynein heavy chain 14

Related Diseases

Diseases Alias
Brain Compression

Compression Of Brain
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03846 DNAH14 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DNAH14 VGNC VGNC:49870
Bos taurus DNAH14 VGNC VGNC:106713
Felis catus DNAH14 VGNC VGNC:107867
Mus musculus DNAH14 MGD MGI:2444525
Rattus norvegicus DNAH14 RGD RGD:1582826