1. Gene
  2. UHMK1 - U2AF homology motif kinase 1 Gene

UHMK1 - U2AF homology motif kinase 1 Gene

Homo sapiens

Also known as KIS; KIST; P-CIP2

Gene ID: 127933 | Gene type: protein coding

About UHMK1

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:162,497,174-162,529,631 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 5 paralogues. Ubiquitous expression in kidney (RPKM 18.6), lymph node (RPKM 18.0) and 25 other tissues.

Summary

The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

UHMK1 Products(3)

mRNA Protein Name
NM_001184763.1 NP_001171692.1 serine/threonine-protein kinase Kist isoform 2
NM_144624.2 NP_653225.2 serine/threonine-protein kinase Kist isoform 3
NM_175866.5 NP_787062.1 serine/threonine-protein kinase Kist isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12093740 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12093740 GOA
Biological Process GO Annotation Evidence Reference Source
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
12093740 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
12093740 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
12093740 GOA
involved in regulation of protein export from nucleus IDA
IDA: Inferred from direct assay
12093740 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
12093740 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UHMK1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (23 - 304)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (348 - 400)

  • 0
  • 100
  • 200
  • 300
  • 419 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Kist

KIS protein kinase

UHMK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
UHMK1 Q8TAS1 SF1 Homo sapiens Q15637
Y2H Fragment Pooling
26420826
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Flinders Island Spotted Fever

Fisf

Thai Tick Typhus

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus UHMK1 VGNC VGNC:66809
Canis familiaris UHMK1 VGNC VGNC:48122
Macaca mulatta UHMK1 VGNC VGNC:79198
Mus musculus UHMK1 MGD MGI:1341908
Rattus norvegicus UHMK1 RGD RGD:2968
Bos taurus UHMK1 VGNC VGNC:36653
Others UHMK1 NCBI