ADH5 - alcohol dehydrogenase 5 (class III), chi polypeptide Gene

Homo sapiens

Also known as FDH; ADHX; ADH-3; AMEDS; BMFS7; FALDH; GSNOR; GSH-FDH; HEL-S-60p

Gene ID: 128 | Gene type: protein coding

About ADH5

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,070,978-99,088,788 (from NCBI)

This gene has 13 transcripts (splice variants), 391 orthologues, 17 paralogues and is associated with 1 phenotype. Ubiquitous expression in endometrium (RPKM 69.1), kidney (RPKM 68.7) and 25 other tissues.

Summary

This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This Enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

ADH5 Products(1)

mRNA	Protein	Name
NM_000671.4	NP_000662.3	alcohol dehydrogenase class-3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables fatty acid binding	IDA IDA: Inferred from direct assay	8460164	GOA
enables formaldehyde dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	8460164	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	6375718	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid omega-oxidation	IDA IDA: Inferred from direct assay	16081420	GOA
involved in response to redox state	IDA IDA: Inferred from direct assay	8460164	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADH5 Protein Structure

ADH_N

ADH_zinc_N

0
100
200
300
374 a.a.

Protein Preferred Names

Protein Names

alcohol dehydrogenase class-3

S-(hydroxymethyl)glutathione dehydrogenase	S-nitrosoglutathione reductase
alcohol dehydrogenase (class III), chi polypeptide	alcohol dehydrogenase class chi chain
alcohol dehydrogenase class-III	epididymis secretory sperm binding protein Li 60p
formaldehyde dehydrogenase	glutathione-dependent formaldehyde dehydrogenase

Related Diseases

Diseases

Alias

Contact Dermatitis

Contact Dermatitis/Eczema	Contact Eczema
Dermatitis Venenata	Dermatitis, Venenata
Dermatitis Contact	Dermatitis, Contact

Thyroid Dyshormonogenesis 3

TDH3	Hypothyroidism, Congenital, Due To Dyshormonogenesis, 3
Thyroid Hormonogenesis, Genetic Defect In, 3	Genetic Defect In Thyroid Hormonogenesis 3
Chdh3	Congenital Hypothyroidism Due To Dyshormonogenesis Type 3
Genetic Defect In Thyroid Hormonogenesis Type 3

Familial Thyroid Dyshormonogenesis

Thyroid Dyshormonogenesis

Familial Dyshormonogenetic Goiter

Proliferative Type Fibrocystic Change Of Breast

Fibrocystic Change, Proliferative Type With Atypia	Fibrocystic Disease, Proliferative Type With Atypia
Proliferating Lesion Of Breast Without Atypia	Proliferating Lesion Of The Breast Without Atypia
Proliferative Fibrocystic Change	Breast Fibrocystic Change, Proliferative Type

Breast Intraductal Proliferative Lesion

Intraductal Proliferative Lesion

Intraductal Proliferative Lesion Of The Breast

Pharyngitis

Acute Pharyngitis	Chronic Pharyngitis
Acute Sore Throat	Chronic Sore Throat
Persistent Sore Throat	Pharyngeal Diseases
Chronic Pharyn/Nasopharyngitis	Chronic Pharyngitis And Nasopharyngitis
Inflamed Throat	Pharyngeal Disease
Pharyngeal Disorder	Pharyngitis - Acute
Sore Throat - Chronic	Acute Pharyngitis Nos
Acute Sore Throat Nos	Acute Throat Inflammation
Infective Pharyngitis	Infection Of Pharynx
Acute Infective Pharyngitis	Acute Infective Pharyngitis Nos
Acute Pharyngeal Inflammation	Inflammation Of The Throat
Throat Inflammation	Throat Infection
Putrid Pharyngitis	Pharyngeal Inflammation
Pharyngitis Nos	Chronic Throat Pain
Throat Catarrh

Congenital Hypothyroidism

Cretinism	Neonatal Hypothyroidism
Ch	Cht
Congenital Myxedema	Myxedema, Congenital
Endemic Cretinism	Congenital Iodine-Deficiency Syndrome
Fetal Iodine Deficiency Syndrome	Congenital Iodine-Deficiency Hypothyroidism Nos

Substance Dependence

Amed Syndrome, Digenic

Amed Syndrome	AMEDS
Bone Marrow Failure Syndrome 7, Digenic	Bmfs7
Aplastic Anemia-Intellectual Disability-Dwarfism Syndrome

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against	Alcohol Dependence, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Focal Dermal Hypoplasia

Goltz Syndrome	Goltz-Gorlin Syndrome
FDH	FODH
Dhof	Goltz Gorlin Syndrome
Hypoplasia, Dermal, Focal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00370	ADH5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00371	Adh5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00372	Adh5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ADH5	MGD	MGI:87929

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