Cnr1 - cannabinoid receptor 1 (brain) Gene

Mus musculus

Also known as CB1; CB-R; CB1A; CB1B; CB1R

Gene ID: 12801 | Gene type: protein coding

About Cnr1

Chromosome 4: 33,924,593-33,948,831 forward strand.GRCm39:CM000997.3

This gene has 3 transcripts (splice variants), 206 orthologues, 18 paralogues and is associated with 83 phenotypes. Biased expression in cerebellum adult (RPKM 24.), CNS E18 (RPKM 17.4) and 7 other tissues.

Summary

Enables Cannabinoid Receptor activity and voltage-gated Calcium Channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in cannabinoid signaling pathway; retrograde trans-synaptic signaling by endocannabinoid; and trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within axonal fasciculation and glucose homeostasis. Located in several cellular components, including GABA-ergic synapse; growth cone; and presynaptic membrane. Is integral component of mitochondrial membrane and integral component of presynaptic membrane. Is active in glutamatergic synapse and presynapse. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in obesity; schizophrenia; and type 2 diabetes mellitus. Orthologous to human CNR1 (Cannabinoid Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cnr1 Products(4)

mRNA	Protein	Name
NM_007726.5	NP_031752.1	cannabinoid receptor 1
NM_001355021.2	NP_001341950.1	cannabinoid receptor 1
NM_001355020.2	NP_001341949.1	cannabinoid receptor 1
NM_001365881.1	NP_001352810.1	cannabinoid receptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cannabinoid receptor activity	IMP IMP: Inferred from mutant phenotype	27826249	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axonal fasciculation	IMP IMP: Inferred from mutant phenotype	20962221	MGI
acts upstream of or within glucose homeostasis	IPI IPI: Inferred from physical interaction	23954414	MGI
involved in regulation of presynaptic cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	11516401	MGI
involved in regulation of presynaptic cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	11516401	MGI
involved in retrograde trans-synaptic signaling by endocannabinoid	IDA IDA: Inferred from direct assay	11516401	MGI
involved in retrograde trans-synaptic signaling by endocannabinoid	IMP IMP: Inferred from mutant phenotype	11516401	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	11516401	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	11516401	MGI
located in axon	IDA IDA: Inferred from direct assay	20962221	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11516401	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	11516401	MGI
located in growth cone	IDA IDA: Inferred from direct assay	20962221	MGI
is active in mitochondrion	IDA IDA: Inferred from direct assay	27826249	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	27828947	MGI
is active in presynaptic membrane	IMP IMP: Inferred from mutant phenotype	27828947	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cnr1 Protein Structure

7tmA_CB1

0
100
200
300
400
473 a.a.

Protein Preferred Names

Protein Names

cannabinoid receptor 1

brain-type cannabinoid receptor

striatal cannabinoid receptor type 1 protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02914	CNR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02915	Cnr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02916	Cnr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cnr1	NCBI	NCBI:1268

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