MBOAT2 - membrane bound O-acyltransferase domain containing 2 Gene

Homo sapiens

Also known as LPAAT; LPCAT; LPEAT; OACT2; LPCAT4; LPLAT 2; LPLAT13

Gene ID: 129642 | Gene type: protein coding

About MBOAT2

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:8,852,690-9,003,684 (from NCBI)

This gene has 10 transcripts (splice variants), 278 orthologues and 5 paralogues. Broad expression in bone marrow (RPKM 14.5), brain (RPKM 13.4) and 23 other tissues.

Summary

Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]

MBOAT2 Products(4)

mRNA	Protein	Name
NM_001321265.2	NP_001308194.1	lysophospholipid acyltransferase 2 isoform 2
NM_001321266.2	NP_001308195.1	lysophospholipid acyltransferase 2 isoform 3
NM_001321267.2	NP_001308196.1	lysophospholipid acyltransferase 2 isoform 2
NM_138799.4	NP_620154.2	lysophospholipid acyltransferase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-acylglycerophosphocholine O-acyltransferase activity	IDA IDA: Inferred from direct assay	18772128	GOA
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity	IDA IDA: Inferred from direct assay	18772128	GOA
enables 1-acylglycerophosphoserine O-acyltransferase activity	IMP IMP: Inferred from mutant phenotype	18772128	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in phosphatidylcholine acyl-chain remodeling	IDA IDA: Inferred from direct assay	18772128	GOA
involved in phosphatidylethanolamine acyl-chain remodeling	IDA IDA: Inferred from direct assay	18772128	GOA
involved in phosphatidylserine acyl-chain remodeling	IDA IDA: Inferred from direct assay	18772128	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MBOAT2 Protein Structure

MBOAT

0
100
200
300
400
520 a.a.

Protein Preferred Names

Protein Names

lysophospholipid acyltransferase 2

1-acylglycerophosphate O-acyltransferase

Related Diseases

Diseases

Alias

Brachydactyly-Syndactyly Syndrome

BDSD	Brachydactyly-Syndactyly-Oligodactyly Syndrome
Brachydactyly-Syndactyly, Zhao Type	BDSDO

Chanarin-Dorfman Syndrome

Neutral Lipid Storage Disease	CDS
Neutral Lipid Storage Disease With Ichthyosis	Triglyceride Storage Disease With Impaired Long-Chain Fatty Acid Oxidation
Triglyceride Storage Disease With Ichthyosis	Nlsdi
Ichthyotic Neutral Lipid Storage Disease	Dorfman-Chanarin Syndrome
Dcs	Chanarin-Dorfman Disease
Ichthyosiform Erythroderma With Leukocyte Vacuolation	Lipidosis With Triglyceride Storage Disease
Disorder Of Cornification 12	Dorfman Chanarin Syndrome
Neutral Lipid Storage Disease With Ichthyotic	Dorfman-Chanarin Disease

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08194	MBOAT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MBOAT2	RGD	RGD:1305798
Macaca mulatta	MBOAT2	VGNC	VGNC:74573
Canis familiaris	MBOAT2	VGNC	VGNC:49809
Mus musculus	MBOAT2	MGD	MGI:1914466
Felis catus	MBOAT2	VGNC	VGNC:63404
Bos taurus	MBOAT2	VGNC	VGNC:31287

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