2. Gene
  3. Ctsc - cathepsin C Gene

Ctsc - cathepsin C Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CatC; DPP1; DPPI

Gene ID: 13032 | Gene type: protein coding

About Ctsc

Chromosome 7: 87,927,293-87,960,096 forward strand.GRCm39:CM001000.3

This gene has 5 transcripts (splice variants), 233 orthologues, 24 paralogues and is associated with 14 phenotypes. Ubiquitous expression in lung adult (RPKM 8.), mammary gland adult (RPKM 4.8) and 22 other tissues.

Summary

This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the Dipeptidyl Peptidase 1 LIGHT, heavy, and exclusion domain chains, which together comprise one subunit of the homotetrameric Enzyme. This Enzyme has amino dipeptidase activity and may play a role in the activation of granzymes during inflammation. Homozygous knockout mice for this gene exhibit impaired granzyme activation and enhanced survival in a sepsis model. [provided by RefSeq, Aug 2015]

Ctsc Products(4)

mRNA Protein Name
NM_009982.6 NP_034112.3 dipeptidyl peptidase 1 isoform 1 preproprotein
NM_001412310.1 NP_001399239.1 dipeptidyl peptidase 1 isoform 3 preproprotein
NM_001412311.1 NP_001399240.1 dipeptidyl peptidase 1 isoform 4 precursor
NM_001311790.2 NP_001298719.1 dipeptidyl peptidase 1 isoform 2 precursor

Ctsc Protein Structure

CathepsinC_exc

CathepsinC_exc: pfam08773 (24 - 137)

Pox_I6

Pox_I6: cl28439 (167 - 203)

Peptidase_C1A_CathepsinC

Peptidase_C1A_CathepsinC: cd02621 (229 - 458)

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  • 462 a.a.
Protein Preferred Names Protein Names

dipeptidyl peptidase 1

cathepsin J

dipeptidyl peptidase I

dipeptidyl transferase

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-112318A GSK-2793660 Inhibitor 99.91% Phase 1
HY-112318 GSK-2793660 free base Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120709 GSK2793660 hydrochloride Inhibitor / Unkown
HY-RS03325 CTSC Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03326 Ctsc Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03327 Ctsc Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctsc NCBI NCBI:1075