Ctss - cathepsin S Gene

Mus musculus

Also known as Cats

Gene ID: 13040 | Gene type: protein coding

About Ctss

Chromosome 3: 95,434,097-95,463,714 forward strand.GRCm39:CM000996.3

This gene has 2 transcripts (splice variants), 270 orthologues, 24 paralogues and is associated with 21 phenotypes. Broad expression in spleen adult (RPKM 32.7), large intestine adult (RPKM 28.4) and 25 other tissues.

Summary

This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, which encode preproproteins that are proteolytically processed to generate mature protein products. This Enzyme is secreted by antigen-presenting cells during inflammation and may induce pain and itch via activation of G-protein coupled receptors. Homozygous knockout mice for this gene exhibit impaired wound healing, reduced tumorigenesis in a pancreatic Cancer model, and reduced pathogenesis in a myasthenia gravis model. [provided by RefSeq, Aug 2015]

Ctss Products(2)

mRNA	Protein	Name
NM_001267695.2	NP_001254624.2	cathepsin S isoform 1 preproprotein
NM_021281.3	NP_067256.4	cathepsin S isoform 2 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase activity	EXP EXP: Inferred from Experiment	15308097	MGI
enables peptidase activity	IDA IDA: Inferred from direct assay	11854359	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in basement membrane disassembly	IMP IMP: Inferred from mutant phenotype	22952693	MGI
involved in positive regulation of cation channel activity	IDA IDA: Inferred from direct assay	22864553	MGI
acts upstream of or within positive regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	12163455	MGI
acts upstream of or within proteolysis	IDA IDA: Inferred from direct assay	11854359	MGI
involved in proteolysis involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	22952693	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in lysosome	IDA IDA: Inferred from direct assay	11854359	MGI
located in membrane	IDA IDA: Inferred from direct assay	11854359	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctss Protein Structure

Inhibitor_I29

Peptidase_C1

0
100
200
300
340 a.a.

Protein Preferred Names

Protein Names

cathepsin S

Cat S

Recombinant Ctss Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7757	Cathepsin S Protein, Mouse (HEK293, His)	O70370 (V18-I340)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70226	Cathepsin S, human		/	Unkown
HY-RS03344	CTSS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03345	Ctss Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03346	Ctss Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990387	Anti-CTSS/Cathepsin S Antibody (Fsn0503h)		99.28%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctss	NCBI	NCBI:1520

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