COL15A1 - collagen type XV alpha 1 chain Gene

Homo sapiens

Gene ID: 1306 | Gene type: protein coding

About COL15A1

Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:98,911,204-99,070,787 (from NCBI)

This gene has 5 transcripts (splice variants), 179 orthologues and 37 paralogues. Broad expression in placenta (RPKM 113.8), fat (RPKM 52.0) and 17 other tissues.

Summary

This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, May 2013]

COL15A1 Products(1)

mRNA	Protein	Name
NM_001855.5	NP_001846.3	collagen alpha-1(XV) chain precursor

COL15A1 Protein Structure

Laminin_G_3

Collagen

Endostatin

0
300
600
900
1200
1388 a.a.

Protein Preferred Names

Protein Names

collagen alpha-1(XV) chain

collagen XV, alpha-1 polypeptide

Related Diseases

Diseases

Alias

Basal Laminar Drusen

Drusen Of Bruch Membrane	Drusen, Cuticular
Drusen, Early Adult-Onset, Grouped	Cuticular Drusen
Early Adult-Onset Grouped Drusen	BLD
Drusen Cuticular	Drusen Early Adult-Onset Grouped

Ullrich Congenital Muscular Dystrophy 1

Ullrich Congenital Muscular Dystrophy	Ullrich Disease
Ucmd	Ullrich Scleroatonic Muscular Dystrophy
Scleroatonic Muscular Dystrophy	UCMD1
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 22	Lgmdr22
Muscular Dystrophy, Scleroatonic	Late Onset Scleroatonic Familial Myopathy
Congenital Muscular Dystrophy, Ullrich Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02965	COL15A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	COL15A1	RGD	RGD:1310820
Canis familiaris	COL15A1	VGNC	VGNC:39460
Bos taurus	COL15A1	VGNC	VGNC:27556
Mus musculus	COL15A1	MGD	MGI:88449
Macaca mulatta	COL15A1	VGNC	VGNC:103251
Felis catus	COL15A1	VGNC	VGNC:61052
Others	COL15A1	NCBI

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