COL16A1 - collagen type XVI alpha 1 chain Gene

Homo sapiens

Also known as 447AA; FP1572

Gene ID: 1307 | Gene type: protein coding

About COL16A1

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:31,652,263-31,704,017 (from NCBI)

This gene has 17 transcripts (splice variants), 104 orthologues and 37 paralogues. Broad expression in ovary (RPKM 53.1), prostate (RPKM 25.7) and 20 other tissues.

Summary

This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion. [provided by RefSeq, Jul 2008]

COL16A1 Products(1)

mRNA	Protein	Name
NM_001856.4	NP_001847.3	collagen alpha-1(XVI) chain precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables integrin binding	IDA IDA: Inferred from direct assay	16754661	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15165854	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell adhesion	IDA IDA: Inferred from direct assay	16754661	GOA
involved in cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	16754661	GOA
involved in integrin activation	IDA IDA: Inferred from direct assay	16754661	GOA
involved in positive regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	24466237	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COL16A1 Protein Structure

Collagen

0
300
600
900
1200
1500
1604 a.a.

Protein Preferred Names

Protein Names

collagen alpha-1(XVI) chain

alpha 1 type XVI collagen

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02966	COL16A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	COL16A1	RGD	RGD:1310982
Mus musculus	COL16A1	MGD	MGI:1095396
Felis catus	COL16A1	VGNC	VGNC:80174
Canis familiaris	COL16A1	VGNC	VGNC:39461
Macaca mulatta	COL16A1	VGNC	VGNC:71293
Bos taurus	COL16A1	VGNC	VGNC:27557

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