Slc6a3 - solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Gene

Mus musculus

Also known as DAT; Dat1

Gene ID: 13162 | Gene type: protein coding

About Slc6a3

Chromosome 13: 73,684,866-73,726,791 forward strand.GRCm39:CM001006.3

This gene has 1 transcript (splice variant), 166 orthologues, 20 paralogues and is associated with 62 phenotypes. Low expression observed in reference dataset.

Summary

Enables several functions, including dopamine binding activity; dopamine:sodium symporter activity; and protein N-terminus binding activity. Involved in dopamine uptake; hyaloid vascular plexus regression; and neurotransmitter uptake. Acts upstream of or within several processes, including dopamine metabolic process; gland development; and prepulse inhibition. Located in axon and cell surface. Is expressed in genitourinary system; nervous system; spleen; and submandibular gland. Used to study Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and schizophrenia. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a3 Products(1)

mRNA	Protein	Name
NM_010020.3	NP_034150.1	sodium-dependent dopamine transporter

Slc6a3 Protein Structure

SLC5-6-like_sbd

0
100
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300
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619 a.a.

Protein Preferred Names

Protein Names

sodium-dependent dopamine transporter

DA transporter

dopamine transporter 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13308	SLC6A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13309	Slc6a3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13310	Slc6a3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc6a3	NCBI	NCBI:6531

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