Slc6a3 - solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Gene

Mus musculus

Also known as DAT; Dat1

Gene ID: 13162 | Gene type: protein coding

About Slc6a3

Chromosome 13: 73,684,866-73,726,791 forward strand.GRCm39:CM001006.3

This gene has 1 transcript (splice variant), 166 orthologues, 20 paralogues and is associated with 62 phenotypes. Low expression observed in reference dataset.

Summary

Enables several functions, including dopamine binding activity; dopamine:sodium symporter activity; and protein N-terminus binding activity. Involved in dopamine uptake; hyaloid vascular plexus regression; and neurotransmitter uptake. Acts upstream of or within several processes, including dopamine metabolic process; gland development; and prepulse inhibition. Located in axon and cell surface. Is expressed in genitourinary system; nervous system; spleen; and submandibular gland. Used to study Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and schizophrenia. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a3 Products(1)

mRNA	Protein	Name
NM_010020.3	NP_034150.1	sodium-dependent dopamine transporter

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables dopamine binding	IDA IDA: Inferred from direct assay	18671743	MGI
enables dopamine:sodium symporter activity	IDA IDA: Inferred from direct assay	10375632	MGI
enables dopamine:sodium symporter activity	IMP IMP: Inferred from mutant phenotype	9520487	MGI
enables monoamine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20858707	MGI
enables neurotransmitter transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20858707	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17296554	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adenohypophysis development	IMP IMP: Inferred from mutant phenotype	9247269	MGI
acts upstream of or within cognition	IMP IMP: Inferred from mutant phenotype	28855580	MGI
acts upstream of or within dopamine biosynthetic process	IMP IMP: Inferred from mutant phenotype	9520487	MGI
acts upstream of or within dopamine catabolic process	IMP IMP: Inferred from mutant phenotype	9520487	MGI
acts upstream of or within dopamine transport	IMP IMP: Inferred from mutant phenotype	9520487	MGI
involved in dopamine uptake	IMP IMP: Inferred from mutant phenotype	20858707	MGI
involved in hyaloid vascular plexus regression	IDA IDA: Inferred from direct assay	30936473	MGI
acts upstream of or within lactation	IMP IMP: Inferred from mutant phenotype	9247269	MGI
acts upstream of or within locomotory behavior	IGI IGI: Inferred from genetic interaction	11150348	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	11150348	MGI
involved in neurotransmitter transport	IMP IMP: Inferred from mutant phenotype	20858707	MGI
involved in neurotransmitter uptake	IDA IDA: Inferred from direct assay	8628395	MGI
involved in neurotransmitter uptake	IMP IMP: Inferred from mutant phenotype	8628395	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	9247269	MGI
acts upstream of or within prepulse inhibition	IMP IMP: Inferred from mutant phenotype	11150348	MGI
acts upstream of or within regulation of dopamine metabolic process	IMP IMP: Inferred from mutant phenotype	9247269	MGI
acts upstream of or within response to cocaine	IDA IDA: Inferred from direct assay	18671743	MGI
acts upstream of or within sensory perception of smell	IMP IMP: Inferred from mutant phenotype	16765459	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	17761882	MGI
located in axon terminus	IDA IDA: Inferred from direct assay	17296554	MGI
located in cell surface	IDA IDA: Inferred from direct assay	21399631	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc6a3 Protein Structure

SLC5-6-like_sbd

0
100
200
300
400
500
619 a.a.

Protein Preferred Names

Protein Names

sodium-dependent dopamine transporter

DA transporter

dopamine transporter 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13308	SLC6A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13309	Slc6a3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13310	Slc6a3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc6a3	NCBI	NCBI:6531

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