Dbh - dopamine beta hydroxylase Gene

Mus musculus

Gene ID: 13166 | Gene type: protein coding

About Dbh

Chromosome 2: 27,055,245-27,073,212 forward strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 200 orthologues, 2 paralogues and is associated with 22 phenotypes. Restricted expression toward adrenal adult (RPKM 151.1).

Summary

Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Involved in Catecholamine metabolic process; locomotory behavior; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including behavioral response to ethanol; homoiothermy; and learning or memory. Located in secretory granule lumen and secretory granule membrane. Is expressed in several structures, including adrenal gland; alimentary system; and nervous system. Used to study dopamine beta-hydroxylase deficiency. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]

Dbh Products(1)

mRNA	Protein	Name
NM_138942.3	NP_620392.2	dopamine beta-hydroxylase

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	9189272	MGI
acts upstream of or within behavioral response to ethanol	IMP IMP: Inferred from mutant phenotype	10777779	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	15231500	MGI
acts upstream of or within cytokine production	IMP IMP: Inferred from mutant phenotype	10051631	MGI
acts upstream of or within dopamine catabolic process	IMP IMP: Inferred from mutant phenotype	10051631	MGI
involved in dopamine catabolic process	IMP IMP: Inferred from mutant phenotype	7715704	MGI
acts upstream of or within fear response	IMP IMP: Inferred from mutant phenotype	15066288	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	12959968	MGI
acts upstream of or within homoiothermy	IMP IMP: Inferred from mutant phenotype	9139828	MGI
acts upstream of or within leukocyte mediated immunity	IMP IMP: Inferred from mutant phenotype	10051631	MGI
acts upstream of or within leukocyte migration	IMP IMP: Inferred from mutant phenotype	15849236	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	9189272	MGI
involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	27148966	MGI
acts upstream of or within maternal behavior	IMP IMP: Inferred from mutant phenotype	9393852	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	9189272	MGI
acts upstream of or within norepinephrine biosynthetic process	IMP IMP: Inferred from mutant phenotype	9603211	MGI
involved in norepinephrine biosynthetic process	IMP IMP: Inferred from mutant phenotype	7715704	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	9139828	MGI
acts upstream of or within positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	9139828	MGI
acts upstream of or within regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	15849236	MGI
acts upstream of or within regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15849236	MGI
acts upstream of or within regulation of vascular endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15849236	MGI
acts upstream of or within response to amphetamine	IMP IMP: Inferred from mutant phenotype	12370425	MGI
acts upstream of or within response to pain	IMP IMP: Inferred from mutant phenotype	11805341	MGI
acts upstream of vasoconstriction	IMP IMP: Inferred from mutant phenotype	9139828	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	9189272	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in secretory granule lumen	IDA IDA: Inferred from direct assay	7961964	MGI
located in secretory granule membrane	IDA IDA: Inferred from direct assay	7961964	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dbh Protein Structure

DOMON

Cu2_monooxygen

Cu2_monoox_C

0
100
200
300
400
500
622 a.a.

Protein Preferred Names

Protein Names

dopamine beta-hydroxylase

dopamine beta-monooxygenase

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-106004	Zamicastat	Inhibitor	≥98.0%	Phase 2
HY-14838	Etamicastat	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N7204	4-Hydroxyderricin		99.97%	Unkown
HY-14838A	Etamicastat hydrochloride	Inhibitor	98.14%	Unkown
HY-RS03544	DBH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03545	Dbh Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03546	Dbh Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dbh	NCBI	NCBI:1621

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