2. Gene
  3. Ddc - dopa decarboxylase Gene

Ddc - dopa decarboxylase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Aadc

Gene ID: 13195 | Gene type: protein coding

About Ddc

Summary

Enables aromatic-L-amino-acid decarboxylase activity. Acts upstream of or within response to toxic substance. Located in cytoplasm. Is expressed in several structures, including alimentary system; heart; nervous system; respiratory system; and sensory organ. Used to study aromatic L-amino acid decarboxylase deficiency. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and inherited metabolic disorder. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]

Ddc Products(2)

mRNA Protein Name
NM_001190448.1 NP_001177377.1 aromatic-L-amino-acid decarboxylase
NM_016672.4 NP_057881.1 aromatic-L-amino-acid decarboxylase
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables aromatic-L-amino-acid decarboxylase activity IDA
IDA: Inferred from direct assay
23863468 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
22169008 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
22688335 MGI
acts upstream of or within response to toxic substance IDA
IDA: Inferred from direct assay
7904615 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23010799 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aromatic-L-amino-acid decarboxylase

Recombinant Ddc Proteins

Cat. No. Product Name Accession Purity
HY-P74204 DDC Protein, Mouse (sf9, His) O88533 (M1-E480) ≥95%

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17392 Zalcitabine Inhibitor 99.81% Yes
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-139997 DDC-01-163 Degrader / Unkown
HY-151048 JBJ-07-149 Inhibitor / Unkown
HY-156179 DDC 2′,3′-O-disulfate Inhibitor / Unkown
HY-156180 DDC 3′-O-β-D glucuronide / Unkown
HY-163203 DDC18-8A Inhibitor / Unkown
HY-163461 4F-DDC Inhibitor / Unkown
HY-170351 NH2-PEG2-OMs / Unkown
HY-RS03608 DDC Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-170350 Pomalidomide-PEG2-OMs / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddc NCBI NCBI:1644
Canis familiaris Ddc NCBI NCBI:606852
Macaca fascicularis Ddc NCBI NCBI:102119567