ENPP6 - ectonucleotide pyrophosphatase/phosphodiesterase 6 Gene

Homo sapiens

Also known as NPP6

Gene ID: 133121 | Gene type: protein coding

About ENPP6

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:184,088,706-184,217,873 (from NCBI)

This gene has 4 transcripts (splice variants), 221 orthologues and 6 paralogues. Biased expression in kidney (RPKM 13.7), ovary (RPKM 7.0) and 5 other tissues.

Summary

Enables glycerophosphocholine cholinephosphodiesterase activity. Involved in choline metabolic process and lipid metabolic process. Located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ENPP6 Products(1)

mRNA	Protein	Name
NM_153343.4	NP_699174.1	glycerophosphocholine cholinephosphodiesterase ENPP6 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glycerophosphocholine cholinephosphodiesterase activity	EXP EXP: Inferred from Experiment	15788404	GOA
enables glycerophosphocholine cholinephosphodiesterase activity	IDA IDA: Inferred from direct assay	15788404	GOA
enables phosphoric diester hydrolase activity	IDA IDA: Inferred from direct assay	15788404	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in choline metabolic process	IDA IDA: Inferred from direct assay	15788404	GOA
involved in lipid metabolic process	IDA IDA: Inferred from direct assay	15788404	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	15788404	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15788404	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENPP6 Protein Structure

Phosphodiest

0
100
200
300
400
440 a.a.

Protein Preferred Names

Protein Names

glycerophosphocholine cholinephosphodiesterase ENPP6

B830047L21Rik

Related Diseases

Diseases

Alias

Bartter Syndrome, Type 1, Antenatal

Hyperprostaglandin E Syndrome 1	Bartter Disease Type 1
BARTS1	Bartter Syndrome, Type 1
Bartter Syndrome Type 1	Hypokalemic Alkalosis With Hypercalciuria Antenatal 1
Hypokalemic Alkalosis With Hypercalciuria 1, Antenatal	Bartter Syndrome Type 1 Antenatal
Hypokalemic Alkalosis With Hypercalciuria 1 Antenatal	Bartter Syndrome Antenatal Type 1
Antenatal Bartter Syndrome Type 1	Bartter Syndrome Type I
Bartter Syndrome 1, Antenatal	Abs1
Antenatal Bartter Syndrome 1	Bs1
Bartter Syndrome, Antenatal Type 1	Antley-Bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04392	ENPP6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ENPP6	RGD	RGD:1311645
Canis familiaris	ENPP6	VGNC	VGNC:40377
Macaca mulatta	ENPP6	VGNC	VGNC:72089
Mus musculus	ENPP6	MGD	MGI:2445171
Felis catus	ENPP6	VGNC	VGNC:61876
Bos taurus	ENPP6	VGNC	VGNC:28507

Name
Email *

	Sorry, but the email address you supplied was invalid.