SLC9B2 - solute carrier family 9 member B2 Gene

Homo sapiens

Also known as NHA2; NHE10; NHEDC2

Gene ID: 133308 | Gene type: protein coding

About SLC9B2

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:103,018,029-103,077,319 (from NCBI)

This gene has 11 transcripts (splice variants), 293 orthologues and 1 paralogue. Broad expression in brain (RPKM 4.9), liver (RPKM 4.7) and 21 other tissues.

Summary

Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive Other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008]

SLC9B2 Products(12)

mRNA	Protein	Name
NM_001300754.2	NP_001287683.1	sodium/hydrogen exchanger 9B2 isoform 2
NM_001300756.2	NP_001287685.1	sodium/hydrogen exchanger 9B2 isoform 3
NM_001370199.1	NP_001357128.1	sodium/hydrogen exchanger 9B2 isoform 4
NM_001370200.1	NP_001357129.1	sodium/hydrogen exchanger 9B2 isoform 5
NM_001370201.1	NP_001357130.1	sodium/hydrogen exchanger 9B2 isoform 1
NM_001370202.1	NP_001357131.1	sodium/hydrogen exchanger 9B2 isoform 1
NM_001370203.1	NP_001357132.1	sodium/hydrogen exchanger 9B2 isoform 2
NM_001370204.1	NP_001357133.1	sodium/hydrogen exchanger 9B2 isoform 2
NM_001370205.1	NP_001357134.1	sodium/hydrogen exchanger 9B2 isoform 3
NM_001370206.1	NP_001357135.1	sodium/hydrogen exchanger 9B2 isoform 4
NM_001370207.1	NP_001357136.1	sodium/hydrogen exchanger 9B2 isoform 4
NM_178833.7	NP_849155.2	sodium/hydrogen exchanger 9B2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	28071645	GOA
enables lithium:proton antiporter activity	IDA IDA: Inferred from direct assay	36177733	GOA
enables lithium:proton antiporter activity	IMP IMP: Inferred from mutant phenotype	18000046	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sodium:proton antiporter activity	EXP EXP: Inferred from Experiment	28154142	GOA
enables sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	36177733	GOA
enables sodium:proton antiporter activity	IMP IMP: Inferred from mutant phenotype	18000046	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lithium ion transport	IDA IDA: Inferred from direct assay	36177733	GOA
involved in sodium ion transport	IDA IDA: Inferred from direct assay	18508966	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	18508966	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18000046	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC9B2 Protein Structure

Na_H_Exchanger

0
100
200
300
400
500
537 a.a.

Protein Preferred Names

Protein Names

sodium/hydrogen exchanger 9B2

NHE domain-containing protein 2

SLC9B2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC9B2	Q86UD5	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	SLC9B2	Q86UD5	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13350	SLC9B2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC9B2	RGD	RGD:1598112
Macaca mulatta	SLC9B2	VGNC	VGNC:77773
Felis catus	SLC9B2	VGNC	VGNC:65440
Canis familiaris	SLC9B2	VGNC	VGNC:54362
Bos taurus	SLC9B2	VGNC	VGNC:34948
Mus musculus	SLC9B2	MGD	MGI:2140077

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