Dll1 - delta like canonical Notch ligand 1 Gene

Mus musculus

Also known as Delta1

Gene ID: 13388 | Gene type: protein coding

About Dll1

Summary

Enables Notch binding activity and scaffold protein binding activity. Involved in several processes, including animal organ development; negative regulation of cell differentiation; and regionalization. Acts upstream of or within several processes, including anterior/posterior pattern specification; negative regulation of cell differentiation; and nephron tubule development. Located in several cellular components, including adherens junction; apical plasma membrane; and membrane raft. Is expressed in several structures, including alimentary system; central nervous system; limb; metanephros; and sensory organ. Orthologous to human DLL1 (delta like canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]

Dll1 Products(2)

mRNA	Protein	Name
NM_001379042.1	NP_001365971.1	delta-like protein 1 precursor
NM_007865.3	NP_031891.2	delta-like protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Notch binding	IPI IPI: Inferred from physical interaction	10958687	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10958687	MGI
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	15908431	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Notch signaling pathway	IEP IEP: Inferred from expression pattern	23688253	MGI
involved in Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	12730124	MGI
involved in Notch signaling pathway involved in arterial endothelial cell fate commitment	IMP IMP: Inferred from mutant phenotype	19144989	MGI
involved in astrocyte development	IMP IMP: Inferred from mutant phenotype	23688253	MGI
acts upstream of or within cell-cell signaling	IDA IDA: Inferred from direct assay	16621992	MGI
involved in cerebellar Purkinje cell layer structural organization	IMP IMP: Inferred from mutant phenotype	23688253	MGI
involved in cerebellar molecular layer formation	IMP IMP: Inferred from mutant phenotype	23688253	MGI
acts upstream of or within compartment pattern specification	IMP IMP: Inferred from mutant phenotype	12001066	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	12730124	MGI
involved in endothelial tip cell fate specification	IMP IMP: Inferred from mutant phenotype	22282195	MGI
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	19562077	MGI
involved in heart looping	IMP IMP: Inferred from mutant phenotype	12730124	MGI
acts upstream of hemocyte differentiation	IDA IDA: Inferred from direct assay	16621992	MGI
acts upstream of or within inhibition of neuroepithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	16495313	MGI
acts upstream of inner ear auditory receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	16495313	MGI
acts upstream of or within inner ear development	IMP IMP: Inferred from mutant phenotype	16495313	MGI
involved in lateral inhibition	IDA IDA: Inferred from direct assay	18997111	MGI
involved in lateral inhibition	IMP IMP: Inferred from mutant phenotype	21915337	MGI
involved in left/right axis specification	IMP IMP: Inferred from mutant phenotype	12730124	MGI
involved in loop of Henle development	IEP IEP: Inferred from expression pattern	15821257	MGI
involved in marginal zone B cell differentiation	IMP IMP: Inferred from mutant phenotype	15146182	MGI
acts upstream of myeloid cell differentiation	IDA IDA: Inferred from direct assay	16621992	MGI
involved in negative regulation of cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	18371447	MGI
acts upstream of or within negative regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	10476967	MGI
involved in negative regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	21238454	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17960184	MGI
involved in negative regulation of epidermal cell differentiation	IMP IMP: Inferred from mutant phenotype	17960184	MGI
involved in negative regulation of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	21915337	MGI
involved in negative regulation of glial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	23688253	MGI
acts upstream of or within negative regulation of hemocyte differentiation	IDA IDA: Inferred from direct assay	16621992	MGI
acts upstream of or within negative regulation of inner ear auditory receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	16495313	MGI
acts upstream of or within negative regulation of myeloid cell differentiation	IDA IDA: Inferred from direct assay	16621992	MGI
involved in negative regulation of myoblast differentiation	IMP IMP: Inferred from mutant phenotype	17194759	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	20081190	MGI
involved in negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	19389377	MGI
involved in nephron development	IMP IMP: Inferred from mutant phenotype	23806616	MGI
acts upstream of neuroepithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	16495313	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	20081190	MGI
involved in neuron fate specification	IDA IDA: Inferred from direct assay	18997111	MGI
involved in neuronal stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	23695674	MGI
involved in organ growth	IMP IMP: Inferred from mutant phenotype	22096075	MGI
acts upstream of or within positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	15574878	MGI
involved in positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	10958687	MGI
involved in positive regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	19144989	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	22096075	MGI
involved in positive regulation of endocytosis	IDA IDA: Inferred from direct assay	18676613	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	11076679	MGI
involved in positive regulation of skeletal muscle tissue growth	IMP IMP: Inferred from mutant phenotype	25220152	MGI
involved in positive regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	22282195	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12730124	MGI
involved in proximal tubule development	IEP IEP: Inferred from expression pattern	15821257	MGI
involved in proximal/distal pattern formation	IMP IMP: Inferred from mutant phenotype	22529374	MGI
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	19562077	MGI
involved in regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	22940113	MGI
involved in regulation of cell division	IMP IMP: Inferred from mutant phenotype	21915337	MGI
involved in regulation of growth	IMP IMP: Inferred from mutant phenotype	19562077	MGI
acts upstream of or within regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	19389377	MGI
involved in regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	18997111	MGI
involved in regulation of skeletal muscle tissue growth	IMP IMP: Inferred from mutant phenotype	17194759	MGI
involved in regulation of somitogenesis	IMP IMP: Inferred from mutant phenotype	26114479	MGI
involved in regulation of vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19144989	MGI
involved in regulation of vascular endothelial growth factor signaling pathway	IMP IMP: Inferred from mutant phenotype	19144989	MGI
involved in retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	19389377	MGI
involved in retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	19389377	MGI
involved in skeletal muscle tissue growth	IMP IMP: Inferred from mutant phenotype	22940113	MGI
involved in skin epidermis development	IMP IMP: Inferred from mutant phenotype	17960184	MGI
acts upstream of or within somite specification	IMP IMP: Inferred from mutant phenotype	14960495	MGI
acts upstream of or within somitogenesis	IGI IGI: Inferred from genetic interaction	15902259	MGI
involved in somitogenesis	IMP IMP: Inferred from mutant phenotype	23072809	MGI
involved in spinal cord development	IMP IMP: Inferred from mutant phenotype	19389377	MGI
involved in type B pancreatic cell development	IMP IMP: Inferred from mutant phenotype	22529374	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	15908431	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	24715457	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	16000382	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	18676613	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16000382	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

delta-like protein 1

delta like-1	delta-like 1
drosophila Delta homolog 1

Recombinant Dll1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72970	Delta-like protein 1/DLL1 Protein, Mouse (HEK293, His)	Q61483 (S22-Q516)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990077	Pidilizumab	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03808	DLL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990253	Anti-Mouse Delta-like protein 1/DLL1 Antibody (HMD1-5)		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dll1	NCBI	NCBI:28514
Rattus norvegicus	Dll1	NCBI	NCBI:84010

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