2. Gene
  3. Dll3 - delta like canonical Notch ligand 3 Gene

Dll3 - delta like canonical Notch ligand 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as pu; pudgy

Gene ID: 13389 | Gene type: protein coding

About Dll3

Summary

Predicted to enable Notch binding activity. Involved in skeletal system development. Acts upstream of or within anterior/posterior pattern specification; negative regulation of neurogenesis; and paraxial mesoderm development. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including blastocyst; central nervous system; future brain; paraxial mesenchyme; and sensory organ. Used to study spondylocostal dysostosis. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis. Orthologous to human DLL3 (delta like canonical Notch ligand 3). [provided by Alliance of Genome Resources, Apr 2022]

Dll3 Products(1)

mRNA Protein Name
NM_007866.2 NP_031892.2 delta-like protein 3 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16000382 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within compartment pattern specification IMP
IMP: Inferred from mutant phenotype
12001066 MGI
acts upstream of or within negative regulation of neurogenesis IDA
IDA: Inferred from direct assay
9272948 MGI
acts upstream of or within paraxial mesoderm development IMP
IMP: Inferred from mutant phenotype
15170697 MGI
involved in skeletal system development IMP
IMP: Inferred from mutant phenotype
11923214 MGI
acts upstream of or within somitogenesis IDA
IDA: Inferred from direct assay
9272948 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
15170697 MGI
acts upstream of or within tissue development IDA
IDA: Inferred from direct assay
9272948 MGI
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
34635817 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

delta-like protein 3

M-Delta-3

delta-like 3

delta3

drosophila Delta homolog 3

Recombinant Dll3 Proteins

Cat. No. Product Name Accession Purity
HY-P77916 Delta-like protein 3/DLL3 Protein, Mouse (HEK293, His) O88516-1 (A25-R488) ≥95%

Related Agents

Approval
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99575 Tarlatamab Inhibitor 98.62% Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-132257 Rovalpituzumab tesirine Inhibitor / Phase 3
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99043 Rovalpituzumab Inhibitor ≥95.0% Phase 3
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-159072 Mal-Val-Ala-PAB-N(SO2Me)-Exatecan 98.00% Unkown
HY-164729 FZ-AD005 / Unkown
HY-RS03809 DLL3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990104 Anti-DLL3 Antibody (anti-DLL3 arm derived from AMG-757) Inhibitor 99.39% Unkown
HY-P990896 FZ-A038 / Unkown
HY-P990920 Gocatamig Inhibitor / Unkown
HY-P991016 Peluntamig / Unkown
HY-P991173 AMG-119 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dll3 NCBI NCBI:10683
Macaca fascicularis Dll3 NCBI NCBI:102115332
Macaca mulatta Dll3 NCBI NCBI:697453