2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. Mal-Val-Ala-PAB-N(SO2Me)-Exatecan

Mal-Val-Ala-PAB-N(SO2Me)-Exatecan (Compound LE14) is a conjugate of an ADC toxin Exatecan (HY-13631) and a linker Mal-Val-Ala-PAB-N(SO2Me). Mal-Val-Ala-PAB-N(SO2Me)-Exatecan can be used for synthesis of ADC FZ-AD005. FZ-AD005 is a delta-like ligand 3 (DLL3, KD=58.3 pM) targeting ADC, that exhibits antitumor efficacy against SCLC cancer.

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Mal-Val-Ala-PAB-N(SO2Me)-Exatecan Chemical Structure

Mal-Val-Ala-PAB-N(SO2Me)-Exatecan Chemical Structure

CAS No. : 2575682-08-3

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Mal-Val-Ala-PAB-N(SO2Me)-Exatecan Related Antibodies

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Description

Mal-Val-Ala-PAB-N(SO2Me)-Exatecan (Compound LE14) is a conjugate of an ADC toxin Exatecan (HY-13631) and a linker Mal-Val-Ala-PAB-N(SO2Me). Mal-Val-Ala-PAB-N(SO2Me)-Exatecan can be used for synthesis of ADC FZ-AD005. FZ-AD005 is a delta-like ligand 3 (DLL3, KD=58.3 pM) targeting ADC, that exhibits antitumor efficacy against SCLC cancer[1][2].

Molecular Weight

1141.22

Formula

C56H65FN8O15S
CAS No.
SMILES

O=C(C=CC1=O)N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C2)=CC=C2COC(N(CCS(C)(=O)=O)COCC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O
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Mal-Val-Ala-PAB-N(SO2Me)-Exatecan Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-Val-Ala-PAB-N(SO2Me)-Exatecan2575682-08-3Drug-Linker Conjugates for ADCSCLCsmall-cell lung cancerRovalpituzumab tesirineRova-Tcynomolgus monkeyNCI-H889NCI-H82NCI-H660LU5236NCI-H1105DMS 53DMS 79 NCI-H2227neuroendocrine prostate cancerNOD/SCID mouseInhibitorinhibitorinhibit

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Mal-Val-Ala-PAB-N(SO2Me)-Exatecan
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