2. Gene
  3. COX7A2 - cytochrome c oxidase subunit 7A2 Gene

COX7A2 - cytochrome c oxidase subunit 7A2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as VIIAL; COX7AL; COX7AL1; COXVIIAL; COXVIIa-L

Gene ID: 1347 | Gene type: protein coding

About COX7A2

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:75,237,675-75,250,298 (from NCBI)

This gene has 9 transcripts (splice variants), 304 orthologues and 2 paralogues. Broad expression in testis (RPKM 131.2), colon (RPKM 111.8) and 25 other tissues.

Summary

Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009]

COX7A2 Products(3)

mRNA Protein Name
NM_001366292.3 NP_001353221.2 cytochrome c oxidase subunit 7A2, mitochondrial
NM_001366293.2 NP_001353222.1 cytochrome c oxidase subunit 7A2, mitochondrial
NM_001865.6 NP_001856.3 cytochrome c oxidase subunit 7A2, mitochondrial

COX7A2 Protein Structure

COX7a

COX7a: Cytochrome c oxidase subunit VII (25 - 81)

  • 0
  • 83 a.a.
Protein Preferred Names Protein Names

cytochrome c oxidase subunit 7A2, mitochondrial

cytochrome c oxidase polypeptide 7A2, mitochondrial

Related Diseases

Diseases Alias
Barrett'S Adenocarcinoma

Barrett Adenocarcinoma

Adenocarcinoma Arising In Barrett'S Mucosa
Neurodegeneration With Brain Iron Accumulation 4

NBIA4

Mpan

Mitochondrial Protein-Associated Neurodegeneration

Nbia Due To C19orf12 Mutation

Neurodegeneration With Brain Iron Accumulation Due To C19orf12 Mutation

Neurodegeneration With Brain Iron Accumulation Type 4

Mitochondrial Membrane Protein Associated Neurodegeneration

Neurodegeneration, With Brain Iron Accumulation, Type 4
Esophagus Adenocarcinoma

Esophageal Adenocarcinoma

Oesophageal Adenocarcinoma

Adenocarcinoma Of Esophagus

Adenocarcinoma Of The Esophagus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03074 COX7A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03075 COX7A2L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus COX7A2 MGD MGI:1316715
Felis catus COX7A2 VGNC VGNC:102408
Rattus norvegicus COX7A2 RGD RGD:68365
Bos taurus COX7A2 VGNC VGNC:53788