2. Gene
  3. TAAR1 - trace amine associated receptor 1 Gene

TAAR1 - trace amine associated receptor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TA1; TAR1; TRAR1

Gene ID: 134864 | Gene type: protein coding

About TAAR1

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:132,643,312-132,659,182 (from NCBI)

This gene has 1 transcript (splice variant), 601 orthologues and 25 paralogues.

Summary

The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]

TAAR1 Products(1)

mRNA Protein Name
NM_138327.4 NP_612200.1 trace amine-associated receptor 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
11723224 GOA
enables trace-amine receptor activity IDA
IDA: Inferred from direct assay
11459929 GOA
Biological Process GO Annotation Evidence Reference Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11723224 GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
31399635 GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
37935376 GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
37935376 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in endomembrane system IDA
IDA: Inferred from direct assay
11723224 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAAR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (40 - 304)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
Protein Preferred Names Protein Names

trace amine-associated receptor 1

trace amine receptor 1

Related Diseases

Diseases Alias
Superficial Urinary Bladder Cancer

Superficial Urinary Bladder Carcinoma

Carcinoma Of Urinary Bladder, Superficial
Hypoparathyroidism-Deafness-Renal Disease Syndrome

Barakat Syndrome

Hypoparathyroidism, Deafness, Renal Disease Syndrome

Hdr Syndrome

Hypoparathyroidism, Sensorineural Deafness, And Renal Disease
Baastrup'S Syndrome

Kissing Spine

Baastrup Syndrome

Kissing Spine, Site Unspecified

Osteoarthrosis Interspinalis

Overriding Of Dorsal Spinous Processes

Localised Idiopathic Skeletal Hyperostosis

Baastrup Disease
Diamond-Blackfan Anemia 7

DBA7

Rpl11-Related Diamond-Blackfan Anemia

Anemia, Diamond-Blackfan, Type 7
Trichothiodystrophy 6, Nonphotosensitive

TTD6

Nonphotosensitive Trichothiodystrophy 6

Trichothiodystrophy 6, Non-Photosensitive
Joubert Syndrome 32

JBTS32
Greig Cephalopolysyndactyly Syndrome

GCPS

Polysyndactyly With Peculiar Skull Shape

Polysyndactyly With Peculiars Skull Shape

Greig Syndrome

Cephalopolysyndactyly Syndrome

Greig Cephalo-Poly-Syndactyly Syndrome

Cephalopolysyndactyly, Greig Syndrome

Aarskog Syndrome
Acrocallosal Syndrome

ACLS

Schinzel Acrocallosal Syndrome

Joubert Syndrome 12

Schinzel Syndrome 1

Acrocallosal Syndrome, Schinzel Type

Hallux Duplication, Postaxial Polydactyly, And Absence Of Corpus Callosum

Acs

Absence Of Corpus Callosum With Unusual Facial Appearance, Mental Deficiency, Duplication Of The Halluces And Polydactyly

Hallux Duplication Postaxial Polydactyly And Absence Of Corpus Callosum

JBTS12

Acrocallosal Syndrome

Pallister-Hall Syndrome

PHS

Hypothalamic Hamartomas

Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, And Postaxial Polydactyly

Hypothalamic Hamartoblastoma Syndrome

Hamartoma Of The Hypothalamus

Pallister Hall Syndrome

Hall-Pallister Syndrome

Hypothalamic Hamartoblastoma Hypopituitarism Imperforate Anus And Postaxial Polydactyly

Hamartoma, Hypothalamic
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-136109 SEP-363856 hydrochloride Agonist 99.57% Phase 3
HY-136109A SEP-363856 Agonist / Phase 3
HY-109157 Ralmitaront Agonist 99.92% Phase 2
Pre-clinical Phase
Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-110098 Ro 5212773 99.85% Unkown
HY-12700 RO5256390 98.75% Unkown
HY-12699 RO5166017 99.48% Unkown
HY-103638 3-Methoxytyramine hydrochloride 98.36% Unkown
HY-108015 RO5263397 98.87% Unkown
HY-103638S 3-Methoxytyramine-d4 hydrochloride ≥99.0% Unkown
HY-42346 ZH8651 Agonist 99.71% Unkown
HY-103054 RO5203648 Agonist 98.05% Unkown
HY-135065 3-Iodothyronamine hydrochloride / Unkown
HY-136109E SEP-363856 mesylate Agonist / Unkown
HY-157955 TAAR1 agonist 1 Agonist / Unkown
HY-157955A TAAR1 agonist 1 hydrochloride Agonist / Unkown
HY-RS14130 TAAR1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W502657 ZH8667 / Unkown
HY-W909149 TAAR1 agonist 3 Agonist / Unkown
HY-W909173 TAAR1 agonist 2 Agonist / Unkown
HY-160001 ZH8659 / Unkown
HY-W634602 (R)-RO5263397 / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TAAR1 VGNC VGNC:83474
Mus musculus TAAR1 MGD MGI:2148258
Bos taurus TAAR1 VGNC VGNC:35553
Felis catus TAAR1 VGNC VGNC:65912
Rattus norvegicus TAAR1 RGD RGD:621621