CD109 - CD109 molecule Gene

Homo sapiens

Also known as p180; r150; CPAMD7

Gene ID: 135228 | Gene type: protein coding

About CD109

Cytogenetic location: 6q13 Genomic coordinates (GRCh38): 6:73,679,192-73,828,313 (from NCBI)

This gene has 5 transcripts (splice variants), 227 orthologues, 8 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 9.8), endometrium (RPKM 7.6) and 21 other tissues.

Summary

This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

CD109 Products(3)

mRNA	Protein	Name
NM_001159587.3	NP_001153059.1	CD109 antigen isoform 2 preproprotein
NM_001159588.3	NP_001153060.1	CD109 antigen isoform 3 preproprotein
NM_133493.5	NP_598000.2	CD109 antigen isoform 1 preproprotein

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	16754747	GOA
involved in negative regulation of wound healing	IDA IDA: Inferred from direct assay	16754747	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD109 Protein Structure

A2M_N

A2M_N_2

A2M

Thiol-ester_cl

A2M_comp

A2M_recep

0
300
600
900
1200
1445 a.a.

Protein Preferred Names

Protein Names

CD109 antigen

150 kDa TGF-beta-1-binding protein

Related Diseases

Diseases

Alias

Fetal And Neonatal Alloimmune Thrombocytopenia

Nait	Neonatal Alloimmune Thrombocytopenia
Fnait

Adenosquamous Gallbladder Carcinoma

Adenosquamous Carcinoma Of Gallbladder	Adenosquamous Carcinoma Of The Gallbladder
Gallbladder Adenosquamous Carcinoma

Gallbladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Gallbladder

Epidermoid Gallbladder Carcinoma

Immunodeficiency 15b

IMD15B

Immunodeficiency, Type 15b

Myxofibrosarcoma

Fibromyxosarcoma	Fibromyxoid Sarcoma
Myxoid Malignant Fibrous Histiocytoma	Dermatofibrosarcoma Protuberans, Myxoid

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02188	CD109 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CD109	VGNC	VGNC:38929
Felis catus	CD109	VGNC	VGNC:60583
Bos taurus	CD109	VGNC	VGNC:27002
Mus musculus	CD109	MGD	MGI:2445221
Rattus norvegicus	CD109	RGD	RGD:1311287
Macaca mulatta	CD109	VGNC	VGNC:70834

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