CPA1 - carboxypeptidase A1 Gene

Homo sapiens

Also known as CPA

Gene ID: 1357 | Gene type: protein coding

About CPA1

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,380,494-130,388,108 (from NCBI)

This gene has 9 transcripts (splice variants), 264 orthologues, 8 paralogues and is associated with 1 phenotype. Restricted expression toward pancreas (RPKM 26661.6).

Summary

This gene encodes a member of the Carboxypeptidase A family of zinc metalloproteases. This Enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic Amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic Cancer. [provided by RefSeq, Jan 2015]

CPA1 Products(1)

mRNA	Protein	Name
NM_001868.4	NP_001859.1	carboxypeptidase A1 preproprotein

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables metallocarboxypeptidase activity	IDA IDA: Inferred from direct assay	20385563	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19179285	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	2920728	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPA1 Protein Structure

Propep_M14

Peptidase_M14

0
100
200
300
419 a.a.

Protein Preferred Names

Protein Names

carboxypeptidase A1

carboxypeptidase A1 (pancreatic)

Recombinant CPA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7732	Carboxypeptidase A1/CPA1 Protein, Human (HEK293, His)	AAH05279.1 (K17-Y419)	≥95%

CPA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82741	Carboxypeptidase A1/A2/B Antibody (YA2486)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Pancreatitis

Mumps Pancreatitis

Pancreatitis, Hereditary

Hereditary Pancreatitis	Chronic Pancreatitis
Hereditary Chronic Pancreatitis	Hp
Pancreatitis, Chronic, Susceptibility To	PCTT
Hpc	Pancreatitis, Chronic
Pancreatitis, Chronic, Protection Against	Autosomal Dominant Hereditary Pancreatitis
Familial Pancreatitis	Cp
Pancreatitis Hereditary

Spermatogenic Failure 24

SPGF24

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Pancreatic Acinar Cell Adenocarcinoma

Pancreatic Acinar Cell Carcinoma

Acinar Cell Adenocarcinoma Of The Pancreas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W044764	2-Benzylsuccinic acid	Inhibitor	99.41%	Unkown
HY-P10231	Ac-Phe-Thiaphe-OH		/	Unkown
HY-RS03080	CPA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CPA1	VGNC	VGNC:39543
Bos taurus	CPA1	VGNC	VGNC:27642
Mus musculus	CPA1	MGD	MGI:88478
Macaca mulatta	CPA1	VGNC	VGNC:71455
Rattus norvegicus	CPA1	RGD	RGD:2388
Felis catus	CPA1	VGNC	VGNC:61111
Others	CPA1	NCBI

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