CPB1 - carboxypeptidase B1 Gene

Homo sapiens

Also known as CPB; PASP; PCPB

Gene ID: 1360 | Gene type: protein coding

About CPB1

Cytogenetic location: 3q24 Genomic coordinates (GRCh38): 3:148,827,811-148,860,187 (from NCBI)

This gene has 10 transcripts (splice variants), 220 orthologues and 8 paralogues. Restricted expression toward pancreas (RPKM 27892.6).

Summary

Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008]

CPB1 Products(1)

mRNA	Protein	Name
NM_001871.3	NP_001862.2	carboxypeptidase B preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables carboxypeptidase activity	IDA IDA: Inferred from direct assay	1370825	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within proteolysis	IDA IDA: Inferred from direct assay	1370825	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPB1 Protein Structure

Propep_M14

Peptidase_M14

0
100
200
300
417 a.a.

Protein Preferred Names

Protein Names

carboxypeptidase B

carboxypeptidase B1 (tissue)

Recombinant CPB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7734	Carboxypeptidase B1/CPB1 Protein, Human (HEK293, His)	P15086 (H16-Y417)	≥95%

Related Diseases

Diseases

Alias

Acute Pancreatitis

Pancreatitis	Pancreatitis, Acute Necrotizing
Pancreatitis Nos	Acute Pancreas Inflammation

Pancreatitis

Mumps Pancreatitis

Alcoholic Pancreatitis

Pancreatitis, Alcoholic

Pancreatitis Alcoholic

Gas Gangrene

Myonecrosis	Gas Bacillus Infection
Gas Gangrene Due To Clostridia	Clostridial Myonecrosis
Clostridial Cellulitis

Cardiomyopathy, Familial Hypertrophic, 10

Hypertrophic Cardiomyopathy 10	CMH10
Cardiomyopathy, Hypertrophic, Mid-Left Ventricular Chamber Type, 2	Cardiomyopathy, Hypertrophic, 10
Cardiomyopathy, Familial Hypertrophic 10	Familial Hypertrophic Cardiomyopathy With Mid-Left Ventricular Chamber Type 2
Mvc2	Cardiomyopathy, Hypertrophic, Familial, Type 10

C Syndrome

Opitz Trigonocephaly Syndrome	Trigonocephaly
Trigonocephaly Syndrome	Trigonocephaly C Syndrome
Opitz C Trigonocephaly	Opitz Trigonocephaly C Syndrome
Otcs	CSYN

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03087	CPB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CPB1	VGNC	VGNC:27645
Mus musculus	CPB1	MGD	MGI:1923953
Canis familiaris	CPB1	VGNC	VGNC:39549
Felis catus	CPB1	VGNC	VGNC:61117
Macaca mulatta	CPB1	VGNC	VGNC:110372
Rattus norvegicus	CPB1	RGD	RGD:2391
Others	CPB1	NCBI

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