KLF14 - KLF transcription factor 14 Gene

Homo sapiens

Also known as BTEB5

Gene ID: 136259 | Gene type: protein coding

About KLF14

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,730,697-130,734,207 (from NCBI)

This gene has 1 transcript (splice variant), 707 orthologues and 22 paralogues.

Summary

This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta Receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013]

KLF14 Products(1)

mRNA	Protein	Name
NM_138693.4	NP_619638.2	Krueppel-like factor 14

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24759103	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24759103	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLF14 Protein Structure

zf-H2C2_2

0
100
200
300
323 a.a.

Protein Preferred Names

Protein Names

Krueppel-like factor 14

BTE-binding protein 5

Related Diseases

Diseases

Alias

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07335	KLF14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KLF14	VGNC	VGNC:102624
Canis familiaris	KLF14	VGNC	VGNC:42433
Mus musculus	KLF14	MGD	MGI:3577024
Rattus norvegicus	KLF14	RGD	RGD:1306012
Macaca mulatta	KLF14	VGNC	VGNC:73890
Bos taurus	KLF14	VGNC	VGNC:106797

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