NACC2 - NACC family member 2 Gene

Homo sapiens

Also known as RBB; BEND9; NAC-2; BTBD14; BTBD31; BTBD14A

Gene ID: 138151 | Gene type: protein coding

About NACC2

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,006,537-136,095,289 (from NCBI)

This gene has 3 transcripts (splice variants), 257 orthologues and 28 paralogues. Ubiquitous expression in brain (RPKM 17.8), fat (RPKM 7.6) and 24 other tissues.

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and protein homooligomerization. Located in chromatin; mitochondrion; and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

NACC2 Products(1)

mRNA	Protein	Name
NM_144653.5	NP_653254.1	nucleus accumbens-associated protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22926524	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22926524	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	22926524	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22926524	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	22926524	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	22926524	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22926524	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	22926524	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22926524	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: Inferred from direct assay	22926524	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	22926524	GOA
involved in protein-containing complex localization	IDA IDA: Inferred from direct assay	22926524	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	22926524	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22926524	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NACC2 Protein Structure

BTB

BEN

0
100
200
300
400
500
587 a.a.

Protein Preferred Names

Protein Names

nucleus accumbens-associated protein 2

BEN domain containing 9

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09003	NACC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NACC2	VGNC	VGNC:43604
Bos taurus	NACC2	VGNC	VGNC:31862
Rattus norvegicus	NACC2	RGD	RGD:1309292
Macaca mulatta	NACC2	VGNC	VGNC:75013
Mus musculus	NACC2	MGD	MGI:1915241
Felis catus	NACC2	VGNC	VGNC:63709

Name
Email *

	Sorry, but the email address you supplied was invalid.