PIP5KL1 - phosphatidylinositol-4-phosphate 5-kinase like 1 Gene

Homo sapiens

Also known as PIPKH

Gene ID: 138429 | Gene type: protein coding

About PIP5KL1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:127,920,881-127,930,777 (from NCBI)

This gene has 12 transcripts (splice variants), 226 orthologues and 6 paralogues. Low expression observed in reference dataset.

Summary

PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM, Jun 2009]

PIP5KL1 Products(2)

mRNA	Protein	Name
NM_001135219.2	NP_001128691.1	phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 1
NM_173492.2	NP_775763.1	phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	19680787	GOA
involved in negative regulation of mitochondrial membrane potential	IDA IDA: Inferred from direct assay	16751333	GOA
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19680787	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	16751333	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIP5KL1 Protein Structure

PIP5K

0
100
200
300
394 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 4-phosphate 5-kinase-like protein 1

PI(4)P 5-kinase-like protein 1

Related Diseases

Diseases

Alias

Chronic Closed-Angle Glaucoma

Anatomical Narrow Angle Glaucoma	Chronic Angle-Closure Glaucoma
Chronic Narrow Angle Glaucoma	Secondary Angle-Closure Glaucoma - Synechial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10569	PIP5KL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PIP5KL1	VGNC	VGNC:64184
Rattus norvegicus	PIP5KL1	RGD	RGD:1597527
Bos taurus	PIP5KL1	VGNC	VGNC:32913
Mus musculus	PIP5KL1	MGD	MGI:2448520
Canis familiaris	PIP5KL1	VGNC	VGNC:44577

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