CRHBP - corticotropin releasing hormone binding protein Gene

Homo sapiens

Also known as CRFBP; CRF-BP

Gene ID: 1393 | Gene type: protein coding

About CRHBP

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:76,953,045-76,981,159 (from NCBI)

This gene has 5 transcripts (splice variants) and 201 orthologues. Biased expression in liver (RPKM 36.1), kidney (RPKM 16.1) and 6 other tissues.

Summary

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived Peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]

CRHBP Products(1)

mRNA	Protein	Name
NM_001882.4	NP_001873.2	corticotropin-releasing factor-binding protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables corticotropin-releasing hormone binding	IDA IDA: Inferred from direct assay	1846945	GOA
enables corticotropin-releasing hormone binding	IPI IPI: Inferred from physical interaction	18234674	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18234674	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral response to ethanol	IMP IMP: Inferred from mutant phenotype	21039637	GOA
involved in cellular response to estradiol stimulus	IDA IDA: Inferred from direct assay	15345745	GOA
involved in cellular response to estrogen stimulus	IDA IDA: Inferred from direct assay	15345745	GOA
involved in cellular response to potassium ion	IDA IDA: Inferred from direct assay	21624661	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	15345745	GOA
involved in female pregnancy	IDA IDA: Inferred from direct assay	18559919	GOA
involved in female pregnancy	IEP IEP: Inferred from expression pattern	1846945	GOA
involved in hormone-mediated signaling pathway	IDA IDA: Inferred from direct assay	18234674	GOA
involved in inflammatory response	IDA IDA: Inferred from direct assay	18559919	GOA
involved in negative regulation of corticotropin secretion	IDA IDA: Inferred from direct assay	1846945	GOA
involved in negative regulation of corticotropin-releasing hormone receptor activity	IDA IDA: Inferred from direct assay	18234674	GOA
involved in regulated exocytosis	IDA IDA: Inferred from direct assay	21624661	GOA
involved in regulation of cellular response to stress	IMP IMP: Inferred from mutant phenotype	21039637	GOA
involved in regulation of corticotropin secretion	IDA IDA: Inferred from direct assay	13150566	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
NOT located in Golgi apparatus	IDA IDA: Inferred from direct assay	21624661	GOA
NOT located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21624661	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	1846945	GOA
located in secretory granule	IDA IDA: Inferred from direct assay	21624661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRHBP Protein Structure

CRF-BP

0
100
200
300
322 a.a.

Protein Preferred Names

Protein Names

corticotropin-releasing factor-binding protein

CRF-binding protein

Recombinant CRHBP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70013	CRHBP Protein, Human (HEK293, His)	P24387 (Y25-L322)	≥95%

Related Diseases

Diseases

Alias

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Hypoadrenocorticism, Familial

Addison Disease	Primary Adrenocortical Insufficiency
Addison'S Disease	Adrenal Gland Hypofunction
Adrenal Hypoplasia	Adrenal Aplasia
Addison Disease, Chronic Adrenal Insufficiency	Primary Hypoadrenalism
Hypoadrenocorticism Familial	Autoimmune Addison Disease
Autoimmune Adrenalitis	Classic Addison Disease
Primary Addison Disease	Addisons Disease
Addison Disease, Susceptibility To	Autoimmune Primary Adrenal Insufficiency
Addison'S Disease Due To Autoimmunity

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Conn'S Syndrome

Cushing Syndrome	Hyperaldosteronism
Primary Hyperaldosteronism	Hypercortisolism
Primary Aldosteronism	Cushing'S Syndrome
Adrenal Gland Hyperfunction	Conn Syndrome
Hyperadrenalism	Ectopic Acth Syndrome
Hyperadrenocorticism	Cushing Disease
Cushing'S Disease	Adrenal Cortex Adenoma
Corticotroph Pituitary Adenoma	Pituitary Corticotroph Micro-Adenoma
Pituitary-Dependent Cushing Syndrome	Pituitary Acth Hypersecretion
Acth Syndrome, Ectopic	Acth-Secreting Pituitary Adenoma
Adrenal Hyperfunction Resulting From Pituitary Acth Excess	Ectopic Adrenocorticotropic Hormone Syndrome
Nodular Primary Adrenocortical Dysplasia	Pituitary Dependent Cushing Syndrome
Pituitary Cushing Syndrome	Pituitary-Dependant Cushing Syndrome
Pituitary-Dependant Hypercortisolism	Pituitary-Dependant Hypercortisolism Disorder
Aldosteronism Primary	Acth Syndrome Ectopic
Adrenal Cushing'S Syndrome	Adrenal Cortical Adenoma
Cushing Syndrome Nos	Cortisol Hypersecretion
Corticoadrenal Hypersecretion	Cushing Syndrome Secondary To Ectopic Acth-Secretion
Ectopic Cushing Syndrome	Hypercortisolism Due To Nonpituitary Tumour
Ectopic Acth - [Adrenocorticotropic Hormone] Secretion	Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome
Idiopathic Aldosteronism	Aldosteronism
Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia	Primary Aldosteronism Due To Adrenal Hyperplasia

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03167	CRHBP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CRHBP	RGD	RGD:2403
Felis catus	CRHBP	VGNC	VGNC:61177
Bos taurus	CRHBP	VGNC	VGNC:27708
Mus musculus	CRHBP	MGD	MGI:88497
Macaca mulatta	CRHBP	VGNC	VGNC:71491
Canis familiaris	CRHBP	VGNC	VGNC:39610
Others	CRHBP	NCBI

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