CRIP1 - cysteine rich protein 1 Gene

Homo sapiens

Also known as CRHP; CRIP; CRP1; CRP-1

Gene ID: 1396 | Gene type: protein coding

About CRIP1

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:105,486,886-105,488,947 (from NCBI)

This gene has 6 transcripts (splice variants), 124 orthologues and 20 paralogues. Broad expression in small intestine (RPKM 154.6), lung (RPKM 120.1) and 20 other tissues.

Summary

Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008]

CRIP1 Products(1)

mRNA	Protein	Name
NM_001311.5	NP_001302.1	cysteine-rich protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptide binding	IDA IDA: Inferred from direct assay	18670594	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	9126610	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to UV-B	IDA IDA: Inferred from direct assay	20415737	GOA
involved in cellular response to antibiotic	IDA IDA: Inferred from direct assay	20415737	GOA
involved in immune response	IEP IEP: Inferred from expression pattern	20415737	GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: Inferred from direct assay	20415737	GOA
involved in prostate gland stromal morphogenesis	IEP IEP: Inferred from expression pattern	9507743	GOA
involved in regulation of gene expression	IEP IEP: Inferred from expression pattern	7999070	GOA
involved in response to zinc ion	IDA IDA: Inferred from direct assay	7999070	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9126610	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRIP1 Protein Structure

LIM

0
77 a.a.

Protein Preferred Names

Protein Names

cysteine-rich protein 1

cysteine-rich heart protein

Related Diseases

Diseases

Alias

Situs Inversus

Situs Inversus Viscerum	Laterality Sequence
Complete Transposition	Siv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03175	CRIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CRIP1	MGD	MGI:88501
Canis familiaris	CRIP1	VGNC	VGNC:50444
Rattus norvegicus	CRIP1	RGD	RGD:1597237
Felis catus	CRIP1	VGNC	VGNC:104381

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