ASB11 - ankyrin repeat and SOCS box containing 11 Gene

Homo sapiens

Gene ID: 140456 | Gene type: protein coding

About ASB11

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:15,281,697-15,315,640 (from NCBI)

This gene has 4 transcripts (splice variants), 144 orthologues and 2 paralogues. Biased expression in heart (RPKM 11.7), stomach (RPKM 1.0) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

ASB11 Products(3)

mRNA	Protein	Name
NM_001012428.2	NP_001012428.1	ankyrin repeat and SOCS box protein 11 isoform b
NM_001201583.2	NP_001188512.1	ankyrin repeat and SOCS box protein 11 isoform c
NM_080873.3	NP_543149.1	ankyrin repeat and SOCS box protein 11 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	24337577	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	31387940	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	31387940	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	38574733	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	24337577	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul5-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	31387940	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	24337577	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASB11 Protein Structure

Ank_2

Ank

Ank_2

SOCS_box

0
100
200
300
323 a.a.

Protein Preferred Names

Protein Names

ankyrin repeat and SOCS box protein 11

ASB-11

Related Diseases

Diseases

Alias

Lacrimal Duct Obstruction

Blocked Lacrimal Canaliculus	Obstruction Of Lacrimal Canaliculus
Obstruction Of Lacrimal Ducts

Myiasis

Infestation By Fly Larvae	Infestation By Maggots
Maggot Infestation	Infestation By Larvae Of Flies
Infestation By Dermatobia	Infestation By Estrus Ovis
Infestation By Oestrus Ovis	Oestriasis
Oestrosis

Cockayne Syndrome B

Cockayne Syndrome Type 2	Cockayne Syndrome, Type B
Cockayne Syndrome Type Ii	CSB
Cockayne Syndrome 2	Cockayne Syndrome Type B
Ckn2	Cockayne Syndrome, Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01060	ASB11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ASB11	VGNC	VGNC:26188
Mus musculus	ASB11	MGD	MGI:1916104
Rattus norvegicus	ASB11	RGD	RGD:1566298
Felis catus	ASB11	VGNC	VGNC:59956
Canis familiaris	ASB11	VGNC	VGNC:38156

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