F2rl2 - coagulation factor II (thrombin) receptor-like 2 Gene

Mus musculus

Also known as PAR3; F730031A08

Gene ID: 14064 | Gene type: protein coding

About F2rl2

Chromosome 13: 95,833,361-95,839,247 forward strand.GRCm39:CM001006.3

This gene has 1 transcript (splice variant), 262 orthologues, 16 paralogues and is associated with 3 phenotypes. Biased expression in liver E14.5 (RPKM 6.6), spleen adult (RPKM 5.4) and 8 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in Phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within blood coagulation and signal transduction. Located in apical plasma membrane. Is expressed in several structures, including central nervous system; liver; retina; skin; and spleen. Orthologous to human F2RL2 (coagulation factor II Thrombin receptor like 2). [provided by Alliance of Genome Resources, Apr 2022]

F2rl2 Products(1)

mRNA	Protein	Name
NM_010170.4	NP_034300.3	proteinase-activated receptor 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables proteinase-activated receptor activity	IGI IGI: Inferred from genetic interaction	26742564	MGI
enables receptor ligand activity	IDA IDA: Inferred from direct assay	26742564	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	26742564	MGI
involved in G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	26742564	MGI
involved in ligand-gated ion channel signaling pathway	IDA IDA: Inferred from direct assay	26742564	MGI
involved in ligand-gated ion channel signaling pathway	IGI IGI: Inferred from genetic interaction	26742564	MGI
involved in positive regulation of insulin secretion	IDA IDA: Inferred from direct assay	26742564	MGI
involved in positive regulation of insulin secretion	IGI IGI: Inferred from genetic interaction	26742564	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16892058	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F2rl2 Protein Structure

7tm_GPCRs

0
100
200
300
369 a.a.

Protein Preferred Names

Protein Names

proteinase-activated receptor 3

PAR-3	Proteinase activated receptor 3 precursor (PAR-3) (Thrombin receptor-like 2) (Coagulation factor II receptor-like 2)
coagulation factor II receptor-like 2	protease-activated receptor 3
thrombin receptor-like 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04637	F2RL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04638	F2rl2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04639	F2rl2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	F2rl2	NCBI	NCBI:2151

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