2. Gene
  3. ZBTB46 - zinc finger and BTB domain containing 46 Gene

ZBTB46 - zinc finger and BTB domain containing 46 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BZEL; BTBD4; RINZF; ZNF340; dJ583P15.7; dJ583P15.8

Gene ID: 140685 | Gene type: protein coding

About ZBTB46

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,743,670-63,833,895 (from NCBI)

This gene has 6 transcripts (splice variants), 201 orthologues and 28 paralogues. Ubiquitous expression in fat (RPKM 6.8), spleen (RPKM 5.8) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of leukocyte differentiation. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB46 Products(2)

mRNA Protein Name
NM_001369741.1 NP_001356670.1 zinc finger and BTB domain-containing protein 46
NM_025224.4 NP_079500.2 zinc finger and BTB domain-containing protein 46
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
29884909 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB46 Protein Structure

BTB

BTB: BTB/POZ domain (21 - 127)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (433 - 457)

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  • 589 a.a.
Protein Preferred Names Protein Names

zinc finger and BTB domain-containing protein 46

BTB (POZ) domain containing 4

Related Diseases

Diseases Alias
Complex Cortical Dysplasia With Other Brain Malformations

Cdcbm

Dysplasia, Cortical, Complex, With Other Brain Malformations

Dysplasia ,Cortical, Complex, With Other Brain Malformations
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15977 ZBTB46 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ZBTB46 VGNC VGNC:54746
Rattus norvegicus ZBTB46 RGD RGD:1307408
Mus musculus ZBTB46 MGD MGI:1919397
Bos taurus ZBTB46 VGNC VGNC:37084
Felis catus ZBTB46 VGNC VGNC:67174
Macaca mulatta ZBTB46 VGNC VGNC:79006