RIMS4 - regulating synaptic membrane exocytosis 4 Gene

Homo sapiens

Also known as RIM4; RIM 4; RIM-4; C20orf190; RIM4gamma; RIM4-gamma

Gene ID: 140730 | Gene type: protein coding

About RIMS4

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,751,808-44,810,546 (from NCBI)

This gene has 2 transcripts (splice variants), 197 orthologues and 4 paralogues. Biased expression in brain (RPKM 10.7), testis (RPKM 10.4) and 8 other tissues.

Summary

Predicted to enable transmembrane transporter binding activity. Predicted to be involved in regulation of membrane potential; regulation of synapse organization; and regulation of synaptic vesicle exocytosis. Predicted to be located in synaptic membrane. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022]

RIMS4 Products(2)

mRNA	Protein	Name
NM_001205317.2	NP_001192246.1	regulating synaptic membrane exocytosis protein 4 isoform 1
NM_182970.4	NP_892015.1	regulating synaptic membrane exocytosis protein 4 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIMS4 Protein Structure

0
100
200
269 a.a.

Protein Preferred Names

Protein Names

regulating synaptic membrane exocytosis protein 4

RIM4 gamma

Related Diseases

Diseases

Alias

Partial Trisomy Distal 4q

Distal Trisomy 4q	Chromosome 4, Partial Trisomy 4q
Distal 4q Trisomy	Dup Syndrome, Partial
Duplication 4q Syndrome, Partial	Partial Trisomy 4q Syndrome
Distal Duplication 4q	Telomeric Duplication 4q
Trisomy 4qter

Heimler Syndrome 2

HMLR2	Peroxisome Biogenesis Disorder 4c
Pbd4c	Peroxisomal Biogenesis Disorder 4c
Heimler Syndrome, Type 2

Cone-Rod Dystrophy 7

CORD7	Dystrophy, Cone-Rod, Type 7
Retinitis Pigmentosa 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11981	RIMS4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RIMS4	MGD	MGI:2674366
Canis familiaris	RIMS4	VGNC	VGNC:45585
Rattus norvegicus	RIMS4	RGD	RGD:628695
Bos taurus	RIMS4	VGNC	VGNC:33974
Macaca mulatta	RIMS4	VGNC	VGNC:76743

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