2. Gene
  3. Acsl1 - acyl-CoA synthetase long-chain family member 1 Gene

Acsl1 - acyl-CoA synthetase long-chain family member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Acs; Acas; FACS; Acas1; Facl2; LACS1; LACS 1

Gene ID: 14081 | Gene type: protein coding

About Acsl1

Summary

The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This Enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Acsl1 Products(4)

mRNA Protein Name
NM_001302163.1 NP_001289092.1 long-chain-fatty-acid--CoA ligase 1
NM_007981.4 NP_032007.2 long-chain-fatty-acid--CoA ligase 1
NM_001302163.1 NP_001289092.1 long-chain-fatty-acid--CoA ligase 1
NM_007981.4 NP_032007.2 long-chain-fatty-acid--CoA ligase 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein serine/threonine kinase activator activity IGI
IGI: Inferred from genetic interaction
20667975 MGI
enables protein serine/threonine kinase activator activity IMP
IMP: Inferred from mutant phenotype
20667975 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within adiponectin-activated signaling pathway IMP
IMP: Inferred from mutant phenotype
20667975 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
20620995 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

long-chain-fatty-acid--CoA ligase 1

acetate-CoA ligase

acetyl-CoA synthetase

acetyl-Coenzyme A synthetase 1 (ADP forming)

arachidonate--CoA ligase

fatty acid Coenzyme A ligase, long chain 2

long-chain acyl-CoA synthetase 1

phytanate--CoA ligase

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16255 Acsl1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00200 ACSL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acsl1 NCBI NCBI:2180