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  3. Ms4a2 - membrane-spanning 4-domains, subfamily A, member 2 Gene

Ms4a2 - membrane-spanning 4-domains, subfamily A, member 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as FcRB; Fce1b; Ms4a1; fcERI; Fcer1b; Fcrbeta

Gene ID: 14126 | Gene type: protein coding

About Ms4a2

Summary

This gene encodes a member of the membrane-spanning 4A family. The encoded protein is the beta subunit of the high affinity IgE receptor and is localized to the membrane. The encoded protein is required for full activation of mast cells, including the release of histamine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Ms4a2 Products(4)

mRNA Protein Name
NM_001276328.1 NP_001263257.1 high affinity immunoglobulin epsilon receptor subunit beta isoform b
NM_001276329.1 NP_001263258.1 high affinity immunoglobulin epsilon receptor subunit beta isoform c
NM_001276330.1 NP_001263259.1 high affinity immunoglobulin epsilon receptor subunit beta isoform d
NM_013516.2 NP_038544.1 high affinity immunoglobulin epsilon receptor subunit beta isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
contributes to IgE binding IDA
IDA: Inferred from direct assay
14764707 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
9000133 MGI
acts upstream of or within signal transduction IDA
IDA: Inferred from direct assay
12192036 MGI
Cellular Component GO Annotation Evidence Reference Source
part of Fc-epsilon receptor I complex IDA
IDA: Inferred from direct assay
14764707 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
2527850 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
2527850 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

high affinity immunoglobulin epsilon receptor subunit beta

Fc receptor, IgE, high affinity I, beta polypeptide

fc epsilon receptor I beta-chain

membrane-spanning 4-domains, subfamily A, member 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08700 MS4A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ms4a2 NCBI NCBI:2206
Macaca fascicularis Ms4a2 NCBI NCBI:102127416
Canis lupus familiaris Ms4a2 NCBI