ASB12 - ankyrin repeat and SOCS box containing 12 Gene

Homo sapiens

Gene ID: 142689 | Gene type: protein coding

About ASB12

Cytogenetic location: Xq11.2 Genomic coordinates (GRCh38): X:64,224,194-64,230,607 (from NCBI)

This gene has 1 transcript (splice variant), 255 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jan 2011]

ASB12 Products(1)

mRNA	Protein	Name
NM_130388.4	NP_569059.3	ankyrin repeat and SOCS box protein 12

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16325183	GOA
contributes to ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	16325183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	16325183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16325183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASB12 Protein Structure

Ank_2

Ank

SOCS_box

0
100
200
300
318 a.a.

Protein Preferred Names

Protein Names

ankyrin repeat and SOCS box protein 12

ankyrin repeat domain-containing SOCS box protein Asb-12

Related Diseases

Diseases

Alias

Osteopathia Striata With Cranial Sclerosis

Hyperostosis Generalisata With Striations	Robinow-Unger Syndrome
OSCS	Osteopathia Striata Cranial Sclerosis
Osteopathia Striata-Cranial Sclerosis Syndrome	Horan-Beighton Syndrome
Os-Cs	Osteopathia Striata - Cranial Sclerosis
Voorhoeve Disease	Osc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01061	ASB12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ASB12	VGNC	VGNC:38157
Bos taurus	ASB12	VGNC	VGNC:26189
Felis catus	ASB12	VGNC	VGNC:59957
Mus musculus	ASB12	MGD	MGI:1917642
Rattus norvegicus	ASB12	RGD	RGD:1561142

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