FGFBP3 - fibroblast growth factor binding protein 3 Gene

Homo sapiens

Also known as FGF-BP3; C10orf13

Gene ID: 143282 | Gene type: protein coding

About FGFBP3

This gene has 1 transcript (splice variant), 133 orthologues and 2 paralogues. Biased expression in brain (RPKM 6.6), prostate (RPKM 0.9) and 13 other tissues.

Summary

Enables Fibroblast Growth Factor binding activity and heparin binding activity. Acts upstream of or within positive regulation of Fibroblast Growth Factor receptor signaling pathway and positive regulation of vascular permeability. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

FGFBP3 Products(1)

mRNA	Protein	Name
NM_152429.5	NP_689642.3	fibroblast growth factor-binding protein 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fibroblast growth factor binding	IPI IPI: Inferred from physical interaction	18669637	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	18669637	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive regulation of fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	18669637	GOA
acts upstream of or within positive regulation of vascular permeability	IDA IDA: Inferred from direct assay	18669637	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	18669637	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGFBP3 Protein Structure

FGF-BP1

0
100
200
258 a.a.

Protein Preferred Names

Protein Names

fibroblast growth factor-binding protein 3

FGF-binding protein 3

Recombinant FGFBP3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76926	FGFBP3 Protein, Human (sf9, His)	Q8TAT2 (R27-G258)	≥95%

Related Diseases

Diseases

Alias

Spinal Muscular Atrophy, Type Iv

SMA4	Spinal Muscular Atrophy, Adult Form
Spinal Muscular Atrophy 4	Spinal Muscular Atrophy-4
Adult Spinal Muscular Atrophy	Spinal Muscular Atrophy, Proximal, Adult, Autosomal Recessive
Proximal Spinal Muscular Atrophy Type 4	Sma Type 4
Sma Type Iv	Sma-Iv
Sma Iv	Spinal Muscular Atrophy Adult Form
Spinal Muscular Atrophy Proximal Adult Autosomal Recessive	Spinal Muscular Atrophy Type Iv
Atrophy, Muscular, Spinal, Type Iv	Myelopathic Muscular Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04910	FGFBP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FGFBP3	MGD	MGI:1919764
Rattus norvegicus	FGFBP3	RGD	RGD:1560326
Canis familiaris	FGFBP3	VGNC	VGNC:40855
Bos taurus	FGFBP3	VGNC	VGNC:28984
Macaca mulatta	FGFBP3	VGNC	VGNC:106049
Others	FGFBP3	NCBI

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