SESN3 - sestrin 3 Gene

Homo sapiens

Also known as SEST3

Gene ID: 143686 | Gene type: protein coding

About SESN3

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:95,165,513-95,232,475 (from NCBI)

This gene has 6 transcripts (splice variants), 161 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 14.9), lymph node (RPKM 14.4) and 24 other tissues.

Summary

This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular Reactive Oxygen Species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FOXO transcription factor. The protein is required for normal regulation of blood glucose, Insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

SESN3 Products(2)

mRNA	Protein	Name
NM_001271594.2	NP_001258523.1	sestrin-3 isoform 2
NM_144665.4	NP_653266.2	sestrin-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25263562	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amino acid starvation	IMP IMP: Inferred from mutant phenotype	25263562	GOA
involved in cellular response to glucose starvation	IMP IMP: Inferred from mutant phenotype	25263562	GOA
involved in negative regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	25263562	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of GATOR2 complex	IDA IDA: Inferred from direct assay	25263562	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	25263562	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SESN3 Protein Structure

PA26

0
100
200
300
400
492 a.a.

Protein Preferred Names

Protein Names

sestrin-3

Related Diseases

Diseases

Alias

Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium	Adenosquamous Carcinoma Of The Endometrium
Endometrial Adenosquamous Cancer	Endometrial Adenosquamous Cell Carcinoma

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12736	SESN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SESN3	VGNC	VGNC:34490
Rattus norvegicus	SESN3	RGD	RGD:1309470
Macaca mulatta	SESN3	VGNC	VGNC:77291
Canis familiaris	SESN3	VGNC	VGNC:46049
Felis catus	SESN3	VGNC	VGNC:65036
Mus musculus	SESN3	MGD	MGI:1922997

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