PTGR2 - prostaglandin reductase 2 Gene

Homo sapiens

Also known as PGR2; ZADH1; HEL-S-298

Gene ID: 145482 | Gene type: protein coding

About PTGR2

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:73,851,831-73,885,726 (from NCBI)

This gene has 7 transcripts (splice variants), 216 orthologues and 17 paralogues. Ubiquitous expression in heart (RPKM 10.6), thyroid (RPKM 9.3) and 24 other tissues.

Summary

This gene encodes an Enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the Peroxisome Proliferator-activated Receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

PTGR2 Products(13)

mRNA	Protein	Name
NM_001146154.2	NP_001139626.1	prostaglandin reductase 2 isoform 1
NM_001146155.3	NP_001139627.1	prostaglandin reductase 2 isoform 1
NM_001371325.1	NP_001358254.1	prostaglandin reductase 2 isoform 1
NM_001371326.1	NP_001358255.1	prostaglandin reductase 2 isoform 2
NM_001371327.1	NP_001358256.1	prostaglandin reductase 2 isoform 3
NM_001371328.1	NP_001358257.1	prostaglandin reductase 2 isoform 3
NM_001371329.1	NP_001358258.1	prostaglandin reductase 2 isoform 3
NM_001371330.1	NP_001358259.1	prostaglandin reductase 2 isoform 4
NM_001371331.1	NP_001358260.1	prostaglandin reductase 2 isoform 4
NM_001371332.1	NP_001358261.1	prostaglandin reductase 2 isoform 4
NM_001371334.1	NP_001358263.1	prostaglandin reductase 2 isoform 5
NM_001371335.1	NP_001358264.1	prostaglandin reductase 2 isoform 6
NM_152444.4	NP_689657.1	prostaglandin reductase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity	IDA IDA: Inferred from direct assay	19000823	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
NOT enables zinc ion binding	IDA IDA: Inferred from direct assay	19000823	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in prostaglandin metabolic process	IDA IDA: Inferred from direct assay	19000823	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGR2 Protein Structure

ADH_zinc_N

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

prostaglandin reductase 2

15-oxoprostaglandin 13-reductase

PTGR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTGR2	Q8N8N7	BEND5	Homo sapiens	Q7L4P6	Y2H Array	32296183
Intra	PTGR2	Q8N8N7	BEND5	Homo sapiens	Q7L4P6	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Primary Hypertrophic Osteoarthropathy

Pachydermoperiostosis Syndrome	Osteoarthropathy, Primary Hypertrophic
Pachydermoperiostosis Of Nail	Idiopathic Hypertrophic Osteoarthropathy
Pho

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122716	PTGR2-IN-1		99.95%	Unkown
HY-138665	HHS-0701	Inhibitor	98.90%	Unkown
HY-RS11391	PTGR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PTGR2	MGD	MGI:1916372
Felis catus	PTGR2	VGNC	VGNC:104610
Macaca mulatta	PTGR2	VGNC	VGNC:99229
Rattus norvegicus	PTGR2	RGD	RGD:1310518

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