2. Gene
  3. PTGR2 - prostaglandin reductase 2 Gene

PTGR2 - prostaglandin reductase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PGR2; ZADH1; HEL-S-298

Gene ID: 145482 | Gene type: protein coding

About PTGR2

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:73,851,831-73,885,726 (from NCBI)

This gene has 7 transcripts (splice variants), 216 orthologues and 17 paralogues. Ubiquitous expression in heart (RPKM 10.6), thyroid (RPKM 9.3) and 24 other tissues.

Summary

This gene encodes an Enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the Peroxisome Proliferator-activated Receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

PTGR2 Products(13)

mRNA Protein Name
NM_001146154.2 NP_001139626.1 prostaglandin reductase 2 isoform 1
NM_001146155.3 NP_001139627.1 prostaglandin reductase 2 isoform 1
NM_001371325.1 NP_001358254.1 prostaglandin reductase 2 isoform 1
NM_001371326.1 NP_001358255.1 prostaglandin reductase 2 isoform 2
NM_001371327.1 NP_001358256.1 prostaglandin reductase 2 isoform 3
NM_001371328.1 NP_001358257.1 prostaglandin reductase 2 isoform 3
NM_001371329.1 NP_001358258.1 prostaglandin reductase 2 isoform 3
NM_001371330.1 NP_001358259.1 prostaglandin reductase 2 isoform 4
NM_001371331.1 NP_001358260.1 prostaglandin reductase 2 isoform 4
NM_001371332.1 NP_001358261.1 prostaglandin reductase 2 isoform 4
NM_001371334.1 NP_001358263.1 prostaglandin reductase 2 isoform 5
NM_001371335.1 NP_001358264.1 prostaglandin reductase 2 isoform 6
NM_152444.4 NP_689657.1 prostaglandin reductase 2 isoform 1

PTGR2 Protein Structure

ADH_zinc_N

ADH_zinc_N: Zinc-binding dehydrogenase (168 - 265)

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  • 351 a.a.
Protein Preferred Names Protein Names

prostaglandin reductase 2

15-oxoprostaglandin 13-reductase

Related Diseases

Diseases Alias
Primary Hypertrophic Osteoarthropathy

Pachydermoperiostosis Syndrome

Osteoarthropathy, Primary Hypertrophic

Pachydermoperiostosis Of Nail

Idiopathic Hypertrophic Osteoarthropathy

Pho
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122716 PTGR2-IN-1 99.95% Unkown
HY-138665 HHS-0701 Inhibitor 98.90% Unkown
HY-RS11391 PTGR2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PTGR2 MGD MGI:1916372
Felis catus PTGR2 VGNC VGNC:104610
Macaca mulatta PTGR2 VGNC VGNC:99229
Rattus norvegicus PTGR2 RGD RGD:1310518