CSPG4 - chondroitin sulfate proteoglycan 4 Gene

Homo sapiens

Also known as NG2; MCSP; MCSPG; MSK16; CSPG4A; HMW-MAA; MEL-CSPG

Gene ID: 1464 | Gene type: protein coding

About CSPG4

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,674,322-75,713,466 (from NCBI)

This gene has 1 transcript (splice variant) and 193 orthologues. Broad expression in fat (RPKM 18.8), placenta (RPKM 10.9) and 19 other tissues.

Summary

A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]

CSPG4 Products(1)

mRNA	Protein	Name
NM_001897.5	NP_001888.2	chondroitin sulfate proteoglycan 4 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein kinase binding	IPI IPI: Inferred from physical interaction	10587647	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	10587647	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	10587647	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSPG4 Protein Structure

Laminin_G_1

Laminin_G_2

0
400
800
1200
1600
2000
2322 a.a.

Protein Preferred Names

Protein Names

chondroitin sulfate proteoglycan 4

chondroitin sulfate proteoglycan 4 (melanoma-associated)

CSPG4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83476	NG2 Antibody (YA3221)	WB, IHC-P, FC	Human

Related Diseases

Diseases

Alias

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Demyelinating Disease

Demyelinating Diseases

Demyelinating Disorder

Chordoma

CHDM	Notochordoma
Notochordal Sarcoma	Chordoma, Susceptibility To
Chordocarcinoma	Chordoepithelioma

Acral Lentiginous Melanoma

Acral Lentiginous Melanoma, Malignant	Malignant Acral Lentiginous Melanoma
Alm	Acral Lentiginous Malignant Melanoma Of Skin
Palmar/Plantar Melanoma	Subungual Melanoma
Acral Lentiginous Malignant Melanoma

Ullrich Congenital Muscular Dystrophy 1

Ullrich Congenital Muscular Dystrophy	Ullrich Disease
Ucmd	Ullrich Scleroatonic Muscular Dystrophy
Scleroatonic Muscular Dystrophy	UCMD1
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 22	Lgmdr22
Muscular Dystrophy, Scleroatonic	Late Onset Scleroatonic Familial Myopathy
Congenital Muscular Dystrophy, Ullrich Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03254	CSPG4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CSPG4	RGD	RGD:619942
Mus musculus	CSPG4	MGD	MGI:2153093
Bos taurus	CSPG4	VGNC	VGNC:57158
Felis catus	CSPG4	VGNC	VGNC:61227
Macaca mulatta	CSPG4	VGNC	VGNC:71525
Canis familiaris	CSPG4	VGNC	VGNC:59107
Macaca fascicularis	CSPG4	NCBI
Others	CSPG4	NCBI

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