RBFOX3 - RNA binding fox-1 homolog 3 Gene

Homo sapiens

Also known as FOX3; NEUN; FOX-3; HRNBP3

Gene ID: 146713 | Gene type: protein coding

About RBFOX3

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:79,089,345-79,665,571 (from NCBI)

This gene has 14 transcripts (splice variants), 265 orthologues and 2 paralogues. Biased expression in brain (RPKM 11.3), prostate (RPKM 4.9) and 4 other tissues.

Summary

This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]

RBFOX3 Products(47)

mRNA	Protein	Name
NM_001082575.3	NP_001076044.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001350451.2	NP_001337380.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001350453.2	NP_001337382.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385804.1	NP_001372733.1	RNA binding protein fox-1 homolog 3 isoform 3
NM_001385805.1	NP_001372734.1	RNA binding protein fox-1 homolog 3 isoform 3
NM_001385806.1	NP_001372735.1	RNA binding protein fox-1 homolog 3 isoform 4
NM_001385807.1	NP_001372736.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385808.1	NP_001372737.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385809.1	NP_001372738.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385810.1	NP_001372739.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385811.1	NP_001372740.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385812.1	NP_001372741.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385813.1	NP_001372742.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385814.1	NP_001372743.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385815.1	NP_001372744.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385816.1	NP_001372745.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385817.1	NP_001372746.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385818.1	NP_001372747.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385819.1	NP_001372748.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385820.1	NP_001372749.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385821.1	NP_001372750.1	RNA binding protein fox-1 homolog 3 isoform 2
NM_001385822.1	NP_001372751.1	RNA binding protein fox-1 homolog 3 isoform 5
NM_001385823.1	NP_001372752.1	RNA binding protein fox-1 homolog 3 isoform 5
NM_001385824.1	NP_001372753.1	RNA binding protein fox-1 homolog 3 isoform 6
NM_001385825.1	NP_001372754.1	RNA binding protein fox-1 homolog 3 isoform 7
NM_001385826.1	NP_001372755.1	RNA binding protein fox-1 homolog 3 isoform 7
NM_001385827.1	NP_001372756.1	RNA binding protein fox-1 homolog 3 isoform 9
NM_001385828.1	NP_001372757.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385829.1	NP_001372758.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385830.1	NP_001372759.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385831.1	NP_001372760.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385832.1	NP_001372761.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385833.1	NP_001372762.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385834.1	NP_001372763.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385835.1	NP_001372764.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385836.1	NP_001372765.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385837.1	NP_001372766.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385838.1	NP_001372767.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385839.1	NP_001372768.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385840.1	NP_001372769.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385841.1	NP_001372770.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385842.1	NP_001372771.1	RNA binding protein fox-1 homolog 3 isoform 1
NM_001385843.1	NP_001372772.1	RNA binding protein fox-1 homolog 3 isoform 8
NM_001385844.1	NP_001372773.1	RNA binding protein fox-1 homolog 3 isoform 8
NM_001385845.1	NP_001372774.1	RNA binding protein fox-1 homolog 3 isoform 8
NM_001385846.1	NP_001372775.1	RNA binding protein fox-1 homolog 3 isoform 8
NM_001385847.1	NP_001372776.1	RNA binding protein fox-1 homolog 3 isoform 8

RBFOX3 Protein Structure

RRM_1

Fox-1_C

0
100
200
312 a.a.

Protein Preferred Names

Protein Names

RNA binding protein fox-1 homolog 3

RNA binding protein, fox-1 homolog 3

Related Diseases

Diseases

Alias

Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy	Benign Rolandic Epilepsy
Epilepsy, Rolandic	Bcects
Benign Childhood Epilepsy With Centrotemporal Spike	Sylvan Seizures
Becrs	Bects
Bre	Benign Epilepsy Of Childhood With Centrotemporal Spikes
Benign Familial Epilepsy Of Childhood With Rolandic Spikes	Centrotemporal Epilepsy

Gangliocytoma

Ganglioneuroma

Gangliocytoma Of Central Nervous System

Occlusion Precerebral Artery

Occlusion And Stenosis Of Multiple And Bilateral Precerebral Arteries

Occlusion And Stenosis Of Precerebral Artery

Carotid Artery Occlusion

Occlusion And Stenosis Of Carotid Artery

Cerebral Artery Occlusion

Central Neurocytoma

Neurocytoma	Neurolipocytoma
Neurocytoma Central

Dysembryoplastic Neuroepithelial Tumor

Dysembryoplastic Neuroepithelial Tumour	Dysembryoplastic Neuroepithelial Neoplasm
Dnet

Clear Cell Ependymoma

Cellular Ependymoma

Cerebellar Liponeurocytoma

Lipomatous Medulloblastoma

Central Neurocytoma

Spinal Cord Oligodendroglioma

Oligodendroglioma Of Spinal Cord

Well Differentiated Spinal Cord Oligodendroglioma

Toxic Encephalopathy

Neurotoxicity	Neurotoxicity Syndromes
Neurotoxicity Syndrome	Encephalopathy, Toxic

Hypertryptophanemia

HYPTRP	Hypertryptophanemia, Familial
Familial Hypertryptophanemia

Focal Epilepsy

Partial Epilepsy	Epilepsies, Partial
Localisation-Related Epilepsy

Corneal Dystrophy, Fleck

Fleck Corneal Dystrophy	Fcd
CFD	Corneal Fleck Dystrophy
Francois-Neetens Speckled Corneal Dystrophy	Corneal Dystrophy, Francois-Neetens Speckled Or Flecked
Corneal Dystrophy Francois-Neetens Speckled Or Flecked	Dystrophy, Corneal, Fleck

Cauda Equina Neoplasm

Tumor Of The Cauda Equina

Neoplasm Of Cauda Equina

Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type

Wilson-Turner Syndrome	WTS
Mrxs6	X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome
Mrxswt	Wilson-Turner X-Linked Mental Retardation Syndrome
Mental Retardation, X-Linked, Syndromic 6	Mental Retardation, X-Linked, With Gynecomastia And Obesity
Intellectual Disability, X-Linked, Syndromic 6	Intellectual Disability, X-Linked, With Gynecomastia And Obesity
Wilson Turner Intellectual Disability Syndrome	X-Linked Intellectual Disability - Gynecomastia - Obesity

Cerebrum Cancer

Cerebral Cancer	Neoplasm Of Cerebrum
Tumor Of Cerebrum	Malignant Neoplasm Of Cerebrum

Encephalomalacia

Macular Degeneration, Age-Related, 14

Age Related Macular Degeneration 14	ARMD14
Macular Degeneration, Age-Related, 14, Reduced Risk Of	Macular Degeneration, Age-Related, Type 14

Supratentorial Cancer

Supratentorial Neoplasms	Brain Neoplasm, Supratentorial
Malignant Supratentorial Tumor	Cancer, Supratentorial

Spinocerebellar Ataxia 45

SCA45

Spinocerebellar Ataxia Type 45

Cerebral Degeneration

Brain Degeneration

Degenerative Brain Disorder

Cerebrovascular Disease

Cerebrovascular Disorder	Cerebrovascular Accident
Cerebrovascular Disorders	Cva
Stroke

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Pervasive Developmental Disorder

Pervasive Development Disorder	Pervasive Developmental Disorders
Pervasive Child Development Disorders	Autistic Behavior
Autism Spectrum Disorders

Specific Developmental Disorder

Disease Of Mental Health

Mental Health

Mental Disorders

Syndromic X-Linked Intellectual Disability

X-Linked Syndromic Intellectual Disability

Pick Disease Of Brain

Pick Disease	Pick'S Disease
Pick Disease Of The Brain	Lobar Atrophy Of Brain
Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions	Behavioral Variant Of Frontotemporal Dementia
Dementia In Pick'S Disease	Lobar Atrophy Of The Brain
Bvftd	Bv-Ftd
PIDB	Picks Disease

Intracranial Cavernous Angioma

Intracranial Cavernoma

Intracranial Cavernous Hemangioma

Intracranial Structure Hemangioma

Angioma Of Intracranial Structure	Hemangioma Of Intracranial Structure
Hemangioma Of Intracranial Structures

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Dementia, Lewy Body

Lewy Body Dementia	Lewy Body Disease
Diffuse Lewy Body Disease	Dementia With Lewy Bodies
DLB	Autosomal Dominant Diffuse Lewy Body Disease
Cortical Lewy Body Disease	Dementia, Lewy Body, Susceptibility To
Lewy Body Dementia, Susceptibility To	Senile Dementia Of The Lewy Body Type
Dementia Of The Lewy Body Type	Lbd
Diffuse Lewy Body Disease With Gaze Palsy	Dysphasic Dementia Hereditary
Lewy Body Type Senile Dementia	Lewy Body Variant Of Alzheimer Disease
Lewy Bodies	Lewy Body
Dlbd - [Diffuse Lewy Body Disease]	Clbd - [Cortical Lewy Body Disease]

Periventricular Nodular Heterotopia

Periventricular Heterotopia	Pvnh
Familial Nodular Heterotopia	Heterotopia, Periventricular
Periventricular Heterotopia, X-Linked

Syndromic Intellectual Disability

Intracranial Berry Aneurysm

Familial Aneurysmal Subarachnoid Hemorrhage	Familial Berry Aneurysm
Familial Intracranial Saccular Aneurysm	Saccular Cerebral Aneurysm
Aneurysm, Intracranial Berry	Aneurysmal Subarachnoid Hemorrhage
Aneurysm, Intracranial Berry, 1

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11726	RBFOX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RBFOX3	MGD	MGI:106368
Canis familiaris	RBFOX3	VGNC	VGNC:45400
Bos taurus	RBFOX3	VGNC	VGNC:33779
Felis catus	RBFOX3	VGNC	VGNC:64517
Rattus norvegicus	RBFOX3	RGD	RGD:1560070
Macaca mulatta	RBFOX3	VGNC	VGNC:76550