RTN4RL1 - reticulon 4 receptor like 1 Gene

Homo sapiens

Also known as NgR3; NGRH2

Gene ID: 146760 | Gene type: protein coding

About RTN4RL1

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,934,677-2,025,334 (from NCBI)

This gene has 1 transcript (splice variant), 268 orthologues and 22 paralogues. Broad expression in brain (RPKM 5.0), fat (RPKM 3.0) and 14 other tissues.

Summary

Enables signaling receptor activity. Predicted to be involved in negative regulation of axon regeneration. Located in cell surface. Is anchored component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RTN4RL1 Products(1)

mRNA	Protein	Name
NM_178568.4	NP_848663.1	reticulon-4 receptor-like 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables signaling receptor activity	IDA IDA: Inferred from direct assay	12694398	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	20463223	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12694398	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RTN4RL1 Protein Structure

LRR_8

0
100
200
300
400
441 a.a.

Protein Preferred Names

Protein Names

reticulon-4 receptor-like 1

Nogo-66 receptor homolog 2

RTN4RL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RTN4RL1	Q86UN2	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	RTN4RL1	Q86UN2	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	RTN4RL1	Q86UN2	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	RTN4RL1	Q86UN2	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	RTN4RL1	Q86UN2	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	RTN4RL1	Q86UN2	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	RTN4RL1	Q86UN2	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	RTN4RL1	Q86UN2	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	RTN4RL1	Q86UN2	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	RTN4RL1	Q86UN2	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RTN4RL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71159	RTN4RL1/NgR3 Protein, Human (HEK293, His)	Q86UN2 (C25-A419)	≥95%

Related Diseases

Diseases

Alias

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12335	RTN4RL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RTN4RL1	VGNC	VGNC:45797
Felis catus	RTN4RL1	VGNC	VGNC:64813
Bos taurus	RTN4RL1	VGNC	VGNC:34207
Rattus norvegicus	RTN4RL1	RGD	RGD:727812
Mus musculus	RTN4RL1	MGD	MGI:2661375
Macaca mulatta	RTN4RL1	VGNC	VGNC:104647
Others	RTN4RL1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.